Persistent molecular remission of refractory acute myeloid leukemia with inv(16)(p13.1q22) in an elderly patient induced by cytarabine ocfosfate hydrate

被引：1

作者：

Arahata, Masahisa ^{[1
]}

Shimizu, Yukihiro ^{[1
]}

Asakura, Hidesaku ^{[2
]}

Nakao, Shinji ^{[3
]}

机构：

[1] Nanto Municipal Hosp, Dept Internal Med, Nanto, Toyama 9320211, Japan

[2] Kanazawa Univ, Grad Sch Med Sci, Dept Internal Med 3, Kanazawa, Ishikawa, Japan

[3] Kanazawa Univ, Grad Sch Med Sci, Dept Cellular Transplantat Biol, Div Canc Med, Kanazawa, Ishikawa, Japan

来源：

JOURNAL OF HEMATOLOGY & ONCOLOGY | 2015年 / 8卷

关键词：

Cytarabine ocfosfate hydrate; Acute myeloid leukemia; Inv(16)(p13.1q22); Refractory; Elderly; MYELODYSPLASTIC SYNDROME; PROGNOSTIC-FACTORS; GUIDELINES; MANAGEMENT; ADULTS; AML; AGE;

D O I：

10.1186/s13045-014-0100-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The prognosis of relapsed acute myeloid leukemia (AML) in elderly patients is dismal, even if the AML exhibits a good prognostic karyotype, such as inv(16)(p13.1q22). We present a 72-year-old female with AML with inv(16) (p13.1q22) who suffered five episodes of relapse with temporary complete remission. Maintenance chemotherapy with oral cytarabine ocfosfate hydrate eventually produced persistent molecular complete remission of her AML that had not been induced by conventional regimens including intensive chemotherapy and low dose cytarabine therapy. The high level of tolerability to oral cytarabine ocfosfate hydrate may offer elderly patients with this type of AML a good chance for a cure.

引用

页数：5

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