A report on mood and cognitive outcomes with right unilateral ultrabrief pulsewidth (0.3 ms) ECT and retrospective comparison with standard pulsewidth right unilateral ECT

被引:53
作者
Colleen, Loo
Sheehan, Patrick
Pigot, Melissa
Lyndon, William
机构
[1] Prince Wales Hosp, Black Dog Inst, Randwick, NSW 2031, Australia
[2] Univ New S Wales, Sch Psychiat, Kensington, NSW 2033, Australia
[3] Northside Clin, Sydney, NSW, Australia
[4] St George Hosp, Sydney, NSW, Australia
[5] Univ Sydney, Dept Psychol Med, Sydney, NSW 2006, Australia
基金
英国医学研究理事会;
关键词
electroconvulsive therapy; ultrabrief pulsewidth; right unilateral ECT; cognitive side effects; efficacy; depression;
D O I
10.1016/j.jad.2007.06.012
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Electroconvulsive therapy (ECT) is a highly effective treatment for depression but its use is limited by the risk of cognitive side effects. This study explored the potential of a novel approach, ultrabrief pulsewidth (0.3 ms) right unilateral (RUL-UB) ECT, to minimise cognitive effects while preserving efficacy. Methods: Mood and neuropsychological functioning were objectively rated in 30 patients over a course of RUL-UB ECT at 6 times seizure threshold. Results (mood outcomes, ECT treatment parameters) were compared with a retrospectively assessed group of 30 age and gender matched patients who received RUL ECT (1.0 ms pulsewidth, 3.5 times seizure threshold) at the same hospital. Results: Six treatments of RUL-UB ECT resulted in relatively few cognitive side effects, compared to reports of previous studies. The number of responders did not differ between groups but significantly more treatments were required in the RUL-UB group, suggesting a slower speed of response. Limitations: Patients were not randomised to the two forms of ECT and data was obtained retrospectively in the RUL ECT comparison group. Conclusions: This study suggests that RUL-UB ECT can be effective in treating depression while incurring lesser cognitive side effects than a commonly used form of RUL ECT, but a greater number of treatments may be required for response. (C) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码:277 / 281
页数:5
相关论文
共 19 条
[1]  
Abrams R., 2002, Electroconvulsive Therapy, V4th
[2]  
Benton AL., 1976, MULTILINGUAL APHASIA
[3]   Clinical efficacy and cognitive side effects of bifrontal versus right unilateral electroconvulsive therapy (ECT): A short-term randomised controlled trial in pharmaco-resistant major depression [J].
Eschweiler, Gerhard W. ;
Vonthein, Reinhard ;
Bode, Ruediger ;
Huell, Michael ;
Conca, Andreas ;
Peters, Oliver ;
Mende-Lechler, Stefan ;
Peters, Julia ;
Klecha, Dorothee ;
Prapotnik, Michael ;
DiPauli, Jan ;
Wild, Barbara ;
Plewnia, Christian ;
Bartels, Mathias ;
Schlotter, Wilfried .
JOURNAL OF AFFECTIVE DISORDERS, 2007, 101 (1-3) :149-157
[4]   MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].
FOLSTEIN, MF ;
FOLSTEIN, SE ;
MCHUGH, PR .
JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198
[5]   THE AUTOBIOGRAPHICAL MEMORY INTERVIEW - A NEW ASSESSMENT OF AUTOBIOGRAPHICAL AND PERSONAL SEMANTIC MEMORY IN AMNESIC PATIENTS [J].
KOPELMAN, MD ;
WILSON, BA ;
BADDELEY, AD .
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY, 1989, 11 (05) :724-744
[6]   Recent advances in optimizing electroconvulsive therapy [J].
Loo, CK ;
Schweitzer, I ;
Pratt, C .
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, 2006, 40 (08) :632-638
[7]   HALF A CENTURY OF RESEARCH ON THE STROOP EFFECT - AN INTEGRATIVE REVIEW [J].
MACLEOD, CM .
PSYCHOLOGICAL BULLETIN, 1991, 109 (02) :163-203
[8]   Titrated moderately suprathreshold vs fixed high-dose right unilateral electroconvulsive therapy -: Acute antidepressant and cognitive effects [J].
McCall, WV ;
Reboussin, DM ;
Weiner, RD ;
Sackheim, HA .
ARCHIVES OF GENERAL PSYCHIATRY, 2000, 57 (05) :438-444
[9]   Markedly suprathreshold right unilateral ECT versus minimally suprathreshold bilateral ECT: Antidepressant and memory effects [J].
McCall, WV ;
Dunn, A ;
Rosenquist, PB ;
Hughes, D .
JOURNAL OF ECT, 2002, 18 (03) :126-129
[10]   NEW DEPRESSION SCALE DESIGNED TO BE SENSITIVE TO CHANGE [J].
MONTGOMERY, SA ;
ASBERG, M .
BRITISH JOURNAL OF PSYCHIATRY, 1979, 134 (APR) :382-389