Zinc-induced dimerization of the amyloid-β metal-binding domain 1-16 is mediated by residues 11-14

被引：63

作者：

Kozin, Sergey A. ^{[1
,2
]}

Mezentsev, Yuri V. ^{[2
]}

Kulikova, Alexandra A. ^{[1
]}

Indeykina, Maria I. ^{[1
,3
]}

Golovin, Andrey V. ^{[4
]}

Ivanov, Alexis S. ^{[2
]}

Tsvetkov, Philipp O. ^{[1
,2
]}

Makarov, Alexander A. ^{[1
]}

机构：

[1] Russian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow 119991, Russia

[2] Russian Acad Med Sci, Orekhovich Inst Biomed Chem, Moscow 119832, Russia

[3] Emanuel Inst Biochem Phys, Moscow 119334, Russia

[4] Moscow MV Lomonosov State Univ, Bioengn & Bioinformat Dept, Moscow 119992, Russia

来源：

MOLECULAR BIOSYSTEMS | 2011年 / 7卷 / 04期

基金：

俄罗斯基础研究基金会;

关键词：

ALZHEIMERS-DISEASE; PEPTIDE;

D O I：

10.1039/c0mb00334d

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Analysis of complex formation between amyloid-beta fragments using surface plasmon resonance biosensing and electrospray mass spectrometry reveals that region 11-14 mediates zinc-induced dimerization of amyloid-beta and may serve as a potential drug target for preventing development and progression of Alzheimer's disease.

引用

页码：1053 / 1055

页数：3

共 12 条

[11] Blood-Borne Amyloid-β Dimer Correlates with Clinical Markers of Alzheimer's Disease [J].

Villemagne, Victor L. ;

Perez, Keyla A. ;

Pike, Kerryn E. ;

Kok, W. Mei ;

Rowe, Christopher C. ;

White, Anthony R. ;

Bourgeat, Pierrick ;

Salvado, Olivier ;

Bedo, Justin ;

Hutton, Craig A. ;

Faux, Noel G. ;

Masters, Colin L. ;

Barnham, Kevin J. .

JOURNAL OF NEUROSCIENCE, 2010, 30 (18) :6315-6322

[12] Structural changes of region 1-16 of the Alzheimer disease amyloid β-peptide upon zinc binding and in vitro aging [J].

Zirah, S ;

Kozin, SA ;

Mazur, AK ;

Blond, A ;

Cheminant, M ;

Ségalas-Milazzo, I ;

Debey, P ;

Rebuffat, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (04) :2151-2161

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