In this paper, we conduct research on the complex computer network security defense strategy based on cloud computing model and big data environment. Because of the distributed application system design and implementation process the limitation of technology, it can't be one hundred percent perfect, there are hidden holes, with the rising of the hacker technology, software, existing vulnerabilities, has become a target for hackers if distributed application system in use process, can't to patch their these holes, once hacked, intrusion into the system which will produce an immeasurable loss. Due to network application system information data, should be based on the physical and logical network channel, in the process of transmission is very vulnerable to hacker attacks, lead to transport data tampering and theft. Therefore, in view of the network data transmission using encryption measures can effectively prevent data security which is meaningful.