Modeling of ATM accumulation and ATM-mediated oscillation of p53

被引：0

作者：

Guo Zhi-guang ^{[1
]}

Zhao Tong-jun ^{[1
]}

Yuan Chang-qing ^{[1
]}

Liu Hui ^{[1
]}

Yang Yue ^{[1
]}

Yu Kun ^{[1
]}

Zeng Ling-bo ^{[1
]}

Zhan Yong ^{[1
]}

机构：

[1] Hebei Univ Technol, Inst Biophys, Tianjin, Peoples R China

来源：

2009 3RD INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICAL ENGINEERING, VOLS 1-11 | 2009年

关键词：

ATM; accumulation; oscillation; bistability; DNA;

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A dynamical model to study the accumulation of ATM is proposed in this work The ATM can accumulate either with low level of DSBs and presence of NBS1 proteins in cells, or with high level of DSBs and absence of NBS1. Both the two ways trigger the cell damage repair system. The interaction in p53 networks responding to DNA damage is discovered in many researches, but the mechanism of initiating oscillation remains unclear. We examine a model shows that the ATM-NBS1 feedback loop exhibits bistability. The bistability has essential roles in the mechanism of initiate oscillation.

引用

页码：627 / 630

页数：4

共 9 条

[1]

Amours D., 2000, NAT GENET, V25, P115

[2]

Chickarmane V., 2005, P53 OSCILLATOR MODEL

[3] Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex [J].

Dupré, A ;

Boyer-Chatenet, L ;

Gautier, J .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2006, 13 (05) :451-457

[4] Bistability in cell signaling: How to make continuous processes discontinuous, and reversible processes irreversible [J].

Ferrell, JE ;

Xiong, W .

CHAOS, 2001, 11 (01) :227-236

[5]

Khosravi R., 1997, SCIENCE, V11, P3471

[6] DNA damage-induced activation of ATM and ATM-dependent signaling pathways [J].

Kurz, EU ;

Lees-Miller, SP .

DNA REPAIR, 2004, 3 (8-9) :889-900

[7]

Leng R., 2006, CELL, V112, P779

[8] A plausible model for the digital response of p53 to DNA damage [J].

Ma, L ;

Wagner, J ;

Rice, JJ ;

Hu, WW ;

Levine, AJ ;

Stolovitzky, GA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (40) :14266-14271

[9] MDMX inhibits the p300/CBP-mediated acetylation of p53 [J].

Sabbatini, P ;

McCormick, F .

DNA AND CELL BIOLOGY, 2002, 21 (07) :519-525

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