Effect of histochrome on brain vessels and research and exploratory activity of senescence-accelerated OXYS rats

被引：23

作者：

Agafonova, I. G. ^{[1
]}

Kolosova, N. G.

Mishchenko, N. P.

Chaikina, E. L.

Stonik, V. A.

机构：

[1] Russian Acad Sci, Pacific Inst Organ Biochem, Far Eastern Div, Vladivostok 690022, Russia

[2] Russian Acad Sci, Siberian Div, Novosibirsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2007年 / 143卷 / 04期

基金：

俄罗斯基础研究基金会;

关键词：

magnetic resonance tomography; chronic ischemia; histochrome; early aging OXYS rats;

D O I：

10.1007/s10517-007-0158-z

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Changes in the diameter of brain vessels and intensity of collateral blood flow typical of chronic ischemia were detected by magnetic resonance imaging in senescence-accelerated OXYS rats demonstrating reduced (compared to Wistar rats) research and exploratory activity. Histochrome (antioxidant drug) produced positive effects on cerebral vessels in OXYS rats by stimulating collateral blood flow and acting as a vasodilator agent. Analysis of correlations showed that these effects of histochrome were closely related to its capacity to activate research and exploratory activity and reduce anxiety of OXYS rats in the open field test.

引用

页码：467 / 471

页数：5

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