Synthesis of 1,4-anhydro-2-deoxy-D-ribitol derivatives from thymidine

被引:1
作者
Serebryany, V [1 ]
Beigelman, L [1 ]
机构
[1] Ribozyme Pharmaceut Inc, Boulder, CO 80301 USA
关键词
D O I
10.1081/NCN-120022952
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
1,2-Dideoxyribose 5-O-succinate, a component of solid support employed in the synthesis of ribozymes, was synthesized from thymidine. The key step was elimination of nucleobase from 2 to afford glycal 3. A number of catalysts for this reaction were tested, resulting in improved and scaleable synthesis. Hydrogenation of the resulting glycal afforded 1,2-dideoxyribose derivative 4 in a high yield.
引用
收藏
页码:1305 / 1307
页数:3
相关论文
共 2 条
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