Heart Transplantation in Children With a Fontan Procedure

Background. Previous studies have reported that children with a prior Fontan procedure have decreased survival after heart transplantation. We examined 190 primary pediatric heart transplants. Methods. Since 1988, 27 (14.2%) of 190 children less than 18 years old undergoing primary heart transplantation had a Fontan procedure 3.7 +/- 4.3 years before transplantation. Compared with 163 (85.8%) non-Fontan primary transplants, the Fontan patients were similar in age (8.2 +/- 5.0 vs 6.5 +/- 6.0 years), presensitization, and pretransplant clinical status. More Fontan patients had prior operations (100% vs 50%; p < 0.0001) and needed pulmonary artery reconstruction (100% vs 23.5%; p < 0.0001). Twelve (44%) had protein-losing enteropathy. Results. Donor ischemic times (211 +/- 72 vs 170 +/- 61 minutes; p = 0.0018) and cardiopulmonary bypass times (197 +/- 91 vs 121 +/- 53 minutes; p < 0.0001) were greater in the Fontan group as were durations of ventilator support (4.9 +/- 6.6 vs 2.6 +/- 3.9 days; p = 0.018) and hospital stay (20.2 +/- 17.5 vs 14.3 +/- 12.4 days; p = 0.0435). The Fontan group had one 30-day mortality. One-year actuarial survival (81.5% vs 84.6%, Fontan vs non-Fontan) and five-year actuarial survival (65.5% vs 66.2%, Fontan vs non-Fontan) were similar, as was rejection incidence at one year (2.0 +/- 2.0 vs 1.7 +/- 1.9 episodes per patient; p = 0.3972). Five Fontan patients (18.5%) required retransplantation 4.9 +/- 3.6 years posttransplant compared with 18 non-Fontan patients (11.0%) retransplanted 5.2 +/- 3.4 years posttransplant (p = 0.3346). Conclusions. Contrary to prior reports, we did not identify any early or midterm disadvantage for children undergoing heart transplantation after a previous Fontan procedure despite more complex transplant operations. We contend that carefully selected children with a failing Fontan circulation can do as well as other children with heart transplantation. (Ann Thorac Surg 2011;91:823-30) (C) 2011 by The Society of Thoracic Surgeons