Diversity of Sequence Types and Impact of Fitness Cost among Carbapenem-Resistant Acinetobacter baumannii Isolates from Tripoli, Libya

被引：2
作者：
Abou Fayad, Antoine G. [1 ,2 ,3 ]
Haraoui, Louis-Patrick [4 ]
Sleiman, Ahmad [1 ,2 ,3 ]
Jaafar, Mohamad [1 ,2 ,3 ]
Zorgani, Abdulaziz [5 ]
Matar, Ghassan M. [1 ,2 ,3 ]
Higgins, Paul G. [6 ,7 ]
机构：
[1] Amer Univ Beirut, Fac Med, Dept Expt Pathol Immunol & Microbiol, Beirut, Lebanon
[2] Amer Univ Beirut, Ctr Infect Dis Res, Beirut, Lebanon
[3] WHO Collaborating Ctr Reference & Res Bacteri, Beirut, Lebanon
[4] Univ Sherbrooke, Fac Med & Hlth Sci, Dept Microbiol & Infect Dis, Sherbrooke, PQ, Canada
[5] Natl Ctr Dis Control Libya, Reference Lab, Tripoli, Libya
[6] Univ Cologne, Inst Med Microbiol Immunol & Hyg, Cologne, Germany
[7] German Ctr Infect Res DZIF, Partner Site Bonn Cologne, Cologne, Germany
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2021年 / 65卷 / 08期
关键词：
Acinetobacter baumannii; antimicrobial resistance; carbapenems; fitness cost; UNITED-STATES; IRAQ;
D O I：
10.1128/AAC.00277-21
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We investigated the molecular epidemiology of 21 carbapenem-resistant Acinetobacter baumannii isolates from Libya and assessed their relative fitness. Core genome multilocus sequence typing (MLST) revealed five interhospital transmission clusters. Three clusters were associated with the international clones (IC) IC1, IC2, and IC7. Carbapenem-resistance was associated with bla(OXA-23), bla(GES-11), or bla(NDM-1). Compared to that of A. baumannii DSM 30008, the doubling time was similar over 10 h, but after 16 h, half the isolates grew to higher densities, suggesting a fitness advantage.
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页数：6
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