Genetics and developmental pathology of twinning

被引：58

作者：

Weber, Martin A. ^{[1
]}

Sebire, Neil J. ^{[1
,2
]}

机构：

[1] Great Ormond St Hosp Sick Children, Dept Paediat Pathol, London WC1N 3JH, England

[2] UCL, Inst Child Hlth, London, England

来源：

SEMINARS IN FETAL & NEONATAL MEDICINE | 2010年 / 15卷 / 06期

关键词：

Congenital malformations; Conjoined twins; Perinatal mortality; TRAP sequence; Twin pregnancy; CONJOINED TWINS; PERINATAL-MORTALITY; BIRTH-DEFECTS; FETAL; PREVALENCE; GESTATIONS; SEQUENCE; HEART; RISK;

D O I：

10.1016/j.siny.2010.06.002

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Twin pregnancy is associated with a high risk of congenital malformations. This review covers the risk of such anomalies in both dizygotic and monozygotic twin pregnancies, and discusses current insights into the associations relating to zygosity, chorionicity and genetic factors. The pathological basis of specific malformations unique to the monochorionic twinning process, including conjoined twinning and twin reversed arterial perfusion (TRAP) sequence, is discussed in more detail, and factors contributing to the higher perinatal mortality rate in multiple pregnancies are addressed. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：313 / 318

页数：6

共 47 条

[1] Prevalence of congenital heart defects in Monochorionic/Diamniotic twin gestations - A systematic literature review [J].

Bahtiyar, Mert Ozan ;

Dulay, Antonette T. ;

Weeks, Bevin P. ;

Friedman, Alan H. ;

Copel, Joshua A. .

JOURNAL OF ULTRASOUND IN MEDICINE, 2007, 26 (11) :1491-1498

[2]

Baldwin VJ., 1994, Pathology Multiple Pregnancy, V1st

[3] MULTIPLE PREGNANCY .1. [J].

BENIRSCHKE, K ;

KIM, CK .

NEW ENGLAND JOURNAL OF MEDICINE, 1973, 288 (24) :1276-1284

[4] ACARDIAC AMORPHOUS TWIN WITH PRUNE BELLY SEQUENCE IN THE COTWIN [J].

BUNTINX, IM ;

BOURGEOIS, N ;

BUYTAERT, PM ;

DUMON, JE .

AMERICAN JOURNAL OF MEDICAL GENETICS, 1991, 39 (04) :453-457

[5]

Burn J., 1988, TWINNING TWINS, P7

[6] PERINATAL-MORTALITY AND PREVALENCE OF MAJOR CONGENITAL-MALFORMATIONS OF TWINS IN TAIPEI CITY [J].

CHEN, CJ ;

WANG, CJ ;

YU, MW ;

LEE, TK .

ACTA GENETICAE MEDICAE ET GEMELLOLOGIAE, 1992, 41 (2-3) :197-203

[7] Operative fetoscopy in complicated monochorionic twins: current status and future direction [J].

Chmait, Ramen H. ;

Quintero, Ruben A. .

CURRENT OPINION IN OBSTETRICS & GYNECOLOGY, 2008, 20 (02) :169-174

[8] MONOZYGOTIC TWINNING AND WIEDEMANN-BECKWITH SYNDROME [J].

CLAYTONSMITH, J ;

READ, AP ;

DONNAI, D .

AMERICAN JOURNAL OF MEDICAL GENETICS, 1992, 42 (04) :633-637

[9] THE MULTIVESSEL UMBILICAL-CORD - AN ANTENATAL INDICATOR OF POSSIBLE CONJOINED TWINNING [J].

COHEN, HL ;

SHAPIRO, ML ;

HALLER, JO ;

SCHWARTZ, D .

JOURNAL OF CLINICAL ULTRASOUND, 1992, 20 (04) :278-282

[10]

COTE GB, 1991, AM J HUM GENET, V49, P120

← 1 2 3 4 5 →