A Review of the Clinical and Therapeutic Implications of Neuropathic Pain

被引：19

作者：

Balzani, Eleonora ^{[1
]}

Fanelli, Andrea ^{[2
]}

Malafoglia, Valentina ^{[3
]}

Tenti, Michael ^{[3
]}

Ilari, Sara ^{[4
]}

Corraro, Annette ^{[5
]}

Muscoli, Carolina ^{[4
]}

Raffaeli, William ^{[3
]}

机构：

[1] Univ Turin, Dept Med & Surg, I-10124 Turin, Italy

[2] Ist Ad Alta Specializzaz Polidin Monza, Dept Emergency & Urgency, Anesthesia Intens Care & Pain Therapy Unit, Via Amati 111, I-20900 Monza, Italy

[3] ISAL Fdn Inst Res Pain, I-47922 Rimini, Italy

[4] Magna Graecia Univ Catanzaro, Inst Res Food Safety & Hlth IRC FSH, Dept Hlth Sci, I-88100 Catanzaro, Italy

[5] Leiden Univ, Fac Social & Behav Sci, NL-2311 Leiden, Netherlands

来源：

BIOMEDICINES | 2021年 / 9卷 / 09期

关键词：

neuropathic pain; pain therapy; tailored therapy; DOUBLE-BLIND; PHARMACOLOGICAL MANAGEMENT; POSTHERPETIC NEURALGIA; CIRCULATING MICRORNAS; GENERAL-POPULATION; SCREENING TOOLS; ION-CHANNEL; RECEPTOR; BIOMARKERS; COLD;

D O I：

10.3390/biomedicines9091239

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Understanding neuropathic pain presents several challenges, given the various mechanisms underlying its pathophysiological classification and the lack of suitable tools to assess its diagnosis. Furthermore, the response of this pathology to available drugs is still often unpredictable, leaving the treatment of neuropathic pain still questionable. In addition, the rise of personalized treatments further extends the ramified classification of neuropathic pain. While a few authors have focused on neuropathic pain clustering, by analyzing, for example, the presence of specific TRP channels, others have evaluated the presence of alterations in microRNAs to find tailored therapies. Thus, this review aims to synthesize the available evidence on the topic from a clinical perspective and provide a list of current demonstrations on the treatment of this disease.

引用

页数：14

共 111 条

[1] Physical Therapy Modalities and Rehabilitation Techniques in the Management of Neuropathic Pain [J].