A multicenter, case-control study on risk factors for antepartum stillbirth

被引:29
作者
Facchinetti, Fabio [1 ]
Alberico, Salvatore [2 ]
Benedetto, Chiara [3 ]
Cetin, Irene [4 ]
Cozzolino, Sabrina [5 ]
Di Renzo, Gian Carlo [6 ]
Del Giovane, Cinzia [7 ]
Ferrari, Francesca [1 ]
Mecacci, Federico [8 ]
Menato, Guido [9 ]
Tranquilli, Andrea L. [10 ]
Baronciani, Dante [11 ]
机构
[1] Univ Modena & Reggio Emilia, Mother Infant Dept, Modena, Italy
[2] IRCCS Burlo Garofalo, Dept Obstet & Gynecol, Trieste, Italy
[3] Univ Turin, Dept Obstet & Gynecol, Turin, Italy
[4] Univ Milan, DISG Luigi Sacco, Milan, Italy
[5] Univ Milano Bicocca, Obstet & Gynecol Unit, Monza, Italy
[6] Univ Perugia, Ctr Perinatal & Reprod Med, I-06100 Perugia, Italy
[7] Univ Modena & Reggio Emilia, Dept Oncol Hematol & Resp Dis, Modena, Italy
[8] Univ Florence, Dept Obstet & Gynecol, Florence, Italy
[9] Univ Turin, Obstet & Gynecol Chair A, Turin, Italy
[10] Marche Polytech Univ, Ancona, Italy
[11] AUSL Modena, Ctr Evaluat Effectiveness Hlth Care, Modena, Italy
关键词
Stillbirth; risk factors; preeclampsia; IUGR; obesity; FETAL-DEATH; PERINATAL-MORTALITY; CLASSIFICATION; PREGNANCY; OUTCOMES; PREVENTION; MANAGEMENT; WEIGHT;
D O I
10.3109/14767058.2010.496880
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Study design. aEuro integral Multivariate logistic regression analysis (OR with 95%% CI) was utilized in a prospective multicentre nested case--control study to compare in a 1:2 ratio stillborn of > 22 weeks gestation with matched for gestational age live-born (LB) infants. Intrapartum SB were excluded. Results. aEuro integral Two hundred fifty-four consecutive SBs and 497 LBs were enrolled. Socio-demographic variables were equally distributed. Fetal malformations (7.96, 2.69--23.55), severe intrauterine growth restriction (IUGR) (birthweight < a parts per thousand currency sign5<SUth</SU %%ile) (4.32, 2.27--8.24), BMI > 25 (2.87, 1.90--4.33), and preeclampsia (PE, 0.40, 0.21--0.77) were recognized as independent predictors for SB. At term, only BMI > 25 was associated with SB (7.70, 2.9--20.5). Conclusion. aEuro integral Fetal malformations, severe IUGR and maternal BMI > 25 were associated with a significant increase in the risk of SB; PE presented instead a protective role. Maternal BMI > 25 was the only risk factor for SB identified in term pregnancies.
引用
收藏
页码:407 / 410
页数:4
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