Inhibitory effect of flavonoids from Citrus plants on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors

被引：37
|
作者：
Iwase, Y
Takemura, Y
Ju-ichi, M
Ito, C
Furukawa, H
Kawaii, S
Yano, M
Mou, XY
Takayasu, J
Tokuda, H
Nishino, H
机构：
[1] Mukogawa Womens Univ, Fac Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan
[2] Meijo Univ, Fac Pharm, Tempa Ku, Nagoya, Aichi 4688503, Japan
[3] Natl Inst Fruit Tree Sci, Shizuoka 4240292, Japan
[4] Kyoto Prefectural Univ Med, Dept Biochem, Kamigyo Ku, Kyoto 6020841, Japan
来源：
CANCER LETTERS | 2000年 / 154卷 / 01期
关键词：
Citrus; flavone; anti-tumor promoter; two-stage carcinogenesis;
D O I：
10.1016/S0304-3835(00)00386-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To search for possible anti-tumor promoters, thirteen flavones (1-13) obtained from the peel of Citrus plants were examined for their inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation by a short-term in vitro assay. Of these flavones, 3,5,6,7,8,3',4'-heptamethoxyflavone (HPT) (13) exhibited significant inhibitory effects on the EBV-EA activation induced by the tumor promoter, 12-O-tetradecanoylphorbol 13-acetate (TPA). Further, compound 13 exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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页码：101 / 105
页数：5
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