Inhibitory effect of flavonoids from Citrus plants on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors

被引：37

作者：

Iwase, Y

Takemura, Y

Ju-ichi, M

Ito, C

Furukawa, H

Kawaii, S

Yano, M

Mou, XY

Takayasu, J

Tokuda, H

Nishino, H

机构：

[1] Mukogawa Womens Univ, Fac Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan

[2] Meijo Univ, Fac Pharm, Tempa Ku, Nagoya, Aichi 4688503, Japan

[3] Natl Inst Fruit Tree Sci, Shizuoka 4240292, Japan

[4] Kyoto Prefectural Univ Med, Dept Biochem, Kamigyo Ku, Kyoto 6020841, Japan

来源：

CANCER LETTERS | 2000年 / 154卷 / 01期

关键词：

Citrus; flavone; anti-tumor promoter; two-stage carcinogenesis;

D O I：

10.1016/S0304-3835(00)00386-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To search for possible anti-tumor promoters, thirteen flavones (1-13) obtained from the peel of Citrus plants were examined for their inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation by a short-term in vitro assay. Of these flavones, 3,5,6,7,8,3',4'-heptamethoxyflavone (HPT) (13) exhibited significant inhibitory effects on the EBV-EA activation induced by the tumor promoter, 12-O-tetradecanoylphorbol 13-acetate (TPA). Further, compound 13 exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：101 / 105

页数：5

共 9 条

[1] IMMUNOFLUORESCENCE IN CELLS DERIVED FROM BURKITTS LYMPHOMA [J].