Two new 8-O-4′-type lignans from the stem of Schima superba and their cell growth inhibitory activities against human cancer cell lines

被引：13
|
作者：
Xu, Wen [1 ,2 ]
Wang, Hui [3 ]
Zhou, Guang-Xiong [1 ]
Yao, Xin-Sheng [1 ]
机构：
[1] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Guangdong Key Lab Pharmacodynam Constituents TCM, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China
[2] Guangzhou Univ Chinese Med, Coll Clin Med 2, Guangzhou 510120, Guangdong, Peoples R China
[3] Jinan Univ, Coll Med, Guangzhou 510632, Guangdong, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2010年 / 12卷 / 10期
关键词：
Schima superba; 8-O-4 '-type lignan; cell growth inhibitory activity;
D O I：
10.1080/10286020.2010.508036
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new lignans (1 and 2) were isolated from the EtOH extracts of the stem of Schima superba, and elucidated as (7R,8S)-1-(3,4-dimethoxyphenyl)-2-O-(2-methoxy-4-omegahydroxypropylphenyl)propane-1,3-diol (1) and threo-1-(4-hydroxy-3-methoxyphenyl)-1-methoxy-2-{4-[1-formyl-(E)-vinyl]-2-methoxyphenoxy}-3-propanol (2) by spectral analysis. Compounds 1 and 2 showed cell growth inhibitory activity against HeLa, CNE, HepG-2, and HEp-2 cell lines. Compound 1 exhibited significant cytotoxicities with IC50 values of less than 4g/ml against all the tested cell lines.
引用
收藏
页码：874 / 878
页数：5
相关论文
共 50 条
  • [21] Cytotoxic Activities of Amino Acid-Conjugate Derivatives of Abietane-Type Diterpenoids against Human Cancer Cell Lines
    Ukiya, Motohiko
    Kawaguchi, Takuma
    Ishii, Kenta
    Ogihara, Eri
    Tachi, Yosuke
    Kurita, Masahiro
    Ezaki, Yoichiro
    Fukatsu, Makoto
    Kushi, Yasunori
    Akihisa, Toshihiro
    CHEMISTRY & BIODIVERSITY, 2013, 10 (07) : 1260 - 1268
  • [22] Microbial transformation of 20(S)-protopanaxatriol by Absidia corymbifera and their cytotoxic activities against two human prostate cancer cell lines
    Chen, Guangtong
    Yang, Xue
    Zhai, Xuguang
    Yang, Min
    BIOTECHNOLOGY LETTERS, 2013, 35 (01) : 91 - 95
  • [23] Microbial transformation of 20(S)-protopanaxatriol by Absidia corymbifera and their cytotoxic activities against two human prostate cancer cell lines
    Guangtong Chen
    Xue Yang
    Xuguang Zhai
    Min Yang
    Biotechnology Letters, 2013, 35 : 91 - 95
  • [24] Fischerindoline, a pyrroloindole sesquiterpenoid isolated from Neosartorya pseudofischeri, with in vitro growth inhibitory activity in human cancer cell lines
    Masi, Marco
    Andolfi, Anna
    Mathieu, Veronique
    Boari, Angela
    Cimmino, Alessio
    Banuls, Laetitia Moreno Y.
    Vurro, Maurizio
    Kornienko, Alexander
    Kiss, Robert
    Evidente, Antonio
    TETRAHEDRON, 2013, 69 (35) : 7466 - 7470
  • [25] Isolation of Cancer Stem Cells from Three Human Glioblastoma Cell Lines: Characterization of Two Selected Clones
    Iacopino, Fortunata
    Angelucci, Cristiana
    Piacentini, Roberto
    Biamonte, Filippo
    Mangiola, Annunziato
    Maira, Giulio
    Grassi, Claudio
    Sica, Gigliola
    PLOS ONE, 2014, 9 (08):
  • [26] Quinolone and indole alkaloids from the fruits of Euodia rutaecarpa and their cytotoxicity against two human cancer cell lines
    Zhao, Nan
    Li, Zhan-Lin
    Li, Da-Hong
    Sun, Ya-Ting
    Shan, Dong-Ting
    Bai, Jiao
    Pei, Yue-Hu
    Jing, Yong-Kui
    Hua, Hui-Ming
    PHYTOCHEMISTRY, 2015, 109 : 133 - 139
  • [27] Significant Anti-invasive Activities of α-Mangostin from the Mangosteen Pericarp on two Human Skin Cancer Cell Lines
    Wang, Jing J.
    Sanderson, Barbara J. S.
    Zhang, Wei
    ANTICANCER RESEARCH, 2012, 32 (09) : 3805 - 3816
  • [28] Inhibitory effects of prostaglandin D2 against the proliferation of human colon cancer cell lines and hepatic metastasis from colorectal cancer
    Yoshida, T
    Ohki, S
    Kanazawa, M
    Mizunuma, H
    Kikuchi, Y
    Satoh, H
    Andoh, Y
    Tsuchiya, A
    Abe, R
    SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY, 1998, 28 (07): : 740 - 745
  • [29] Inhibitory effects of prostaglandin D2 against the proliferation of human colon cancer cell lines and hepatic metastasis from colorectal cancer
    Tsuneyuki Yoshida
    Shinji Ohki
    Masashi Kanazawa
    Hiroshi Mizunuma
    Youichi Kikuchi
    Hisayoshi Satoh
    Yoshiroh Andoh
    Atsuo Tsuchiya
    Rikiya Abe
    Surgery Today, 1998, 28 : 740 - 745
  • [30] Cis-unsaturated analogues of 3,8,13,18,23-pentaazapentacosane (BE-4-4-4-4):: Synthesis and growth inhibitory effects on human prostate cancer cell lines
    Reddy, VK
    Sarkar, A
    Valasinas, A
    Marton, LJ
    Basu, HS
    Frydman, B
    JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (03) : 404 - 417
12345