Two new 8-O-4′-type lignans from the stem of Schima superba and their cell growth inhibitory activities against human cancer cell lines

被引：13
|
作者：
Xu, Wen [1 ,2 ]
Wang, Hui [3 ]
Zhou, Guang-Xiong [1 ]
Yao, Xin-Sheng [1 ]
机构：
[1] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Guangdong Key Lab Pharmacodynam Constituents TCM, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China
[2] Guangzhou Univ Chinese Med, Coll Clin Med 2, Guangzhou 510120, Guangdong, Peoples R China
[3] Jinan Univ, Coll Med, Guangzhou 510632, Guangdong, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2010年 / 12卷 / 10期
关键词：
Schima superba; 8-O-4 '-type lignan; cell growth inhibitory activity;
D O I：
10.1080/10286020.2010.508036
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new lignans (1 and 2) were isolated from the EtOH extracts of the stem of Schima superba, and elucidated as (7R,8S)-1-(3,4-dimethoxyphenyl)-2-O-(2-methoxy-4-omegahydroxypropylphenyl)propane-1,3-diol (1) and threo-1-(4-hydroxy-3-methoxyphenyl)-1-methoxy-2-{4-[1-formyl-(E)-vinyl]-2-methoxyphenoxy}-3-propanol (2) by spectral analysis. Compounds 1 and 2 showed cell growth inhibitory activity against HeLa, CNE, HepG-2, and HEp-2 cell lines. Compound 1 exhibited significant cytotoxicities with IC50 values of less than 4g/ml against all the tested cell lines.
引用
收藏
页码：874 / 878
页数：5
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