MR imaging of pulmonary lung nodules during one lung flooding: first morphological evaluation using an ex vivo human lung model

被引:2
作者
Wolfram, Frank [1 ]
Boettcher, Joachim [2 ]
Lesser, Thomas Guenther [1 ]
机构
[1] Friedrich Schiller Univ Jena, Dept Thorac & Vasc Surg, SRH Wald Klinikum Gera, Teaching Hosp, Str Friedens 122, D-07548 Gera, Germany
[2] Friedrich Schiller Univ Jena, Inst Diagnost & Intervent Radiol, SRH Wald Klinikum Gera, Teaching Hosp, Gera, Germany
关键词
MRI; One lung flooding; Lung imaging; Lung cancer; MR intervention; HIFU; RESONANCE; CONTRAST; CHILDREN;
D O I
10.1007/s10334-020-00826-8
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Objectives Magnetic resonance imaging in pulmonary oncology is limited because of unfavourable physical and physiological conditions in ventilated lung. Previous work showed operability of One Lung Flooding using saline in vivo in MR units, and that valuable conditions for ultrasound and thermal-based interventions exist. Therefore, this study investigates the morphological details of human lung during Lung Flooding to evaluate its further value focusing on MR-guided interventions. Materials and methods MR imaging was performed on 20 human lung lobes containing lung cancer and metastases. Lobes were intraoperatively flooded with saline and imaged using T1w Gradient Echo and T2 Spin Echo sequences at 1.5 T. Additionally, six patients received pre-operative MRI. Results During lung flooding, all lung tumours and metastases were visualized and clearly demarked from the surrounding lung parenchyma. The tumour mass appeared hyperintense in T1w and hypointense in T2w MR imaging. Intra-pulmonary bronchial structures were well differentiated in T2w and calcification in T1w MR sequences. Conclusion Superior conditions with new features of lung MRI were found during lung flooding with an unrestricted visualization of malignant nodules and clear demarcation of intra-pulmonary structures. This could lead to new applications of MR-based pulmonary interventions such as laser or focused ultrasound-based thermal ablations.
引用
收藏
页码:537 / 547
页数:11
相关论文
共 34 条
  • [1] CAMERON I L, 1984, Magnetic Resonance Imaging, V2, P97, DOI 10.1016/0730-725X(84)90063-8
  • [2] Evaluation of lung recovery after static administration of three different perfluorocarbons in pigs
    Chenoune, Mourad
    De Rochefort, Ludovic
    Bruneval, Patrick
    Lidouren, Fanny
    Kohlhauer, Matthias
    Seemann, Aurelien
    Ghaleh, Bijan
    Korn, Matthias
    Dubuisson, Rose-Marie
    Ben Yahmed, Anis
    Maitre, Xavier
    Isabey, Daniel
    Ricard, Jean-Damien
    Kerber, Richard E.
    Darrasse, Luc
    Berdeaux, Alain
    Tissier, Renaud
    [J]. BMC PHARMACOLOGY & TOXICOLOGY, 2014, 15 : 53
  • [3] Fast PRF-based MR thermometry using double-echo EPI: in vivo comparison in a clinical hyperthermia setting
    Dadakova, Tetiana
    Gellermann, Johanna
    Voigt, Otilia
    Korvink, Jan Gerrit
    Pavlina, John Matthew
    Hennig, Juergen
    Bock, Michael
    [J]. MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE, 2015, 28 (04) : 305 - 314
  • [4] Lung MRI at 1.5 and 3 tesla
    Fink, Christian
    Puderbach, Michael
    Biederer, Juergen
    Fabel, Michael
    Dietrich, Olaf
    Kauczor, Hans-Ulrich
    Reiser, Maximilian F.
    Schoenberg, Stefan O.
    [J]. INVESTIGATIVE RADIOLOGY, 2007, 42 (06) : 377 - 383
  • [5] Hyperpolarized Gas Magnetic Resonance Lung Imaging in Children and Young Adults
    Flors, Lucia
    Mugler, John P., III
    de Lange, Eduard E.
    Miller, Grady W.
    Mata, Jaime F.
    Tustison, Nick
    Ruset, Iulian C.
    Hersman, F. William
    Altes, Talissa A.
    [J]. JOURNAL OF THORACIC IMAGING, 2016, 31 (05) : 285 - 295
  • [6] Time Efficient 3D Radial UTE Sampling with Fully Automatic Delay Compensation on a Clinical 3T MR Scanner
    Herrmann, Karl-Heinz
    Kraemer, Martin
    Reichenbach, Juergen R.
    [J]. PLOS ONE, 2016, 11 (03):
  • [7] MRI detection of tumor in mouse lung using partial liquid ventilation with a perfluorocarbon-in-water emulsion
    Huang, MQ
    Basse, PH
    Yang, Q
    Horner, JA
    Hichens, TK
    Ho, C
    [J]. MAGNETIC RESONANCE IMAGING, 2004, 22 (05) : 645 - 652
  • [8] Klinzing S, 2000, RES EXP MED, V200, P27
  • [9] Hemodynamics and gas exchange during experimental one-lung fluid flooding in pigs
    Klinzing, S
    Lesser, T
    Schubert, H
    Bloos, F
    Klein, U
    Bartel, M
    [J]. RESEARCH IN EXPERIMENTAL MEDICINE, 1999, 199 (02) : 87 - 94
  • [10] One-lung flooding for video-assisted thoracoscopic surgery in animal experiments on pigs - oxygenation and intrapulmonary shunt
    Klinzing, S
    Lesser, T
    Schubert, H
    Bartel, M
    Klein, U
    [J]. RESEARCH IN EXPERIMENTAL MEDICINE, 2000, 199 (06) : 333 - 340