Polyketides, proteins and genes in fungi: programmed nano-machines begin to reveal their secrets

被引：334
作者：
Cox, Russell J. [1 ]
机构：
[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2007年 / 5卷 / 13期
关键词：
D O I：
10.1039/b704420h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Fungi produce a wide variety of biologically active compounds. Among these, the polyketides form a large and structurally diverse group. These compounds are synthesised by highly programmed and very large iterative multifunctional proteins, the polyketide synthases, with nm dimensions. This review outlines the current state of knowledge regarding the links between gene sequence, protein architecture and biosynthetic programming for fungal polyketide synthases.
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页码：2010 / 2026
页数：17
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