Polyketides, proteins and genes in fungi: programmed nano-machines begin to reveal their secrets

被引：334
作者：
Cox, Russell J. [1 ]
机构：
[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2007年 / 5卷 / 13期
关键词：
D O I：
10.1039/b704420h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Fungi produce a wide variety of biologically active compounds. Among these, the polyketides form a large and structurally diverse group. These compounds are synthesised by highly programmed and very large iterative multifunctional proteins, the polyketide synthases, with nm dimensions. This review outlines the current state of knowledge regarding the links between gene sequence, protein architecture and biosynthetic programming for fungal polyketide synthases.
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页码：2010 / 2026
页数：17
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共 93 条
  • [1] Molecular cloning and characterization of an ML-236B (compactin) biosynthetic gene cluster in Penicillium citrinum
    Abe, Y
    Suzuki, T
    Ono, C
    Iwamoto, K
    Hosobuchi, M
    Yoshikawa, H
    [J]. MOLECULAR GENETICS AND GENOMICS, 2002, 267 (05) : 636 - 646
  • [2] The calicheamicin gene cluster and its iterative type I enediyne PKS
    Ahlert, J
    Shepard, E
    Lomovskaya, N
    Zazopoulos, E
    Staffa, A
    Bachmann, BO
    Huang, KX
    Fonstein, L
    Czisny, A
    Whitwam, RE
    Farnet, CM
    Thorson, JS
    [J]. SCIENCE, 2002, 297 (5584) : 1173 - 1176
  • [3] BIOSYNTHESES OF ANTIBIOTIC A26771B BY PENICILLIUM-TURBATUM AND DEHYDROCURVULARIN BY ALTERNARIA-CINERARIAE - COMPARISON OF STEREOCHEMISTRY OF POLYKETIDE AND FATTY-ACID ENOYL THIOL ESTER REDUCTASES
    ARAI, K
    RAWLINGS, BJ
    YOSHIZAWA, Y
    VEDERAS, JC
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (09) : 3391 - 3399
  • [4] Two polyketide synthase-encoding genes are required for biosynthesis of the polyketide virulence factor, T-toxin, by Cochliobolus heterostrophus
    Baker, SE
    Kroken, S
    Inderbitzin, P
    Asvarak, T
    Li, BY
    Shi, L
    Yoder, OC
    Turgeon, BG
    [J]. MOLECULAR PLANT-MICROBE INTERACTIONS, 2006, 19 (02) : 139 - 149
  • [5] Squalestatin cures prion-infected neurons and protects against prion neurotoxicity
    Bate, C
    Salmona, M
    Diomede, L
    Williams, A
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (15) : 14983 - 14990
  • [6] THE MULTIFUNCTIONAL 6-METHYLSALICYLIC ACID SYNTHASE GENE OF PENICILLIUM-PATULUM - ITS GENE STRUCTURE RELATIVE TO THAT OF OTHER POLYKETIDE SYNTHASES
    BECK, J
    RIPKA, S
    SIEGNER, A
    SCHILTZ, E
    SCHWEIZER, E
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1990, 192 (02): : 487 - 498
  • [7] EXPRESSION OF A FUNCTIONAL FUNGAL POLYKETIDE SYNTHASE IN THE BACTERIUM STREPTOMYCES-COELICOLOR A3(2)
    BEDFORD, DJ
    SCHWEIZER, E
    HOPWOOD, DA
    KHOSLA, C
    [J]. JOURNAL OF BACTERIOLOGY, 1995, 177 (15) : 4544 - 4548
  • [8] Ketosynthase domain probes identify two subclasses of fungal polyketide synthase genes
    Bingle, LEH
    Simpson, TJ
    Lazarus, CM
    [J]. FUNGAL GENETICS AND BIOLOGY, 1999, 26 (03) : 209 - 223
  • [9] STUDIES IN RELATION TO BIOSYNTHESIS .1. SOME POSSIBLE ROUTES TO DERIVATIVES OF ORCINOL AND PHLOROGLUCINOL
    BIRCH, AJ
    DONOVAN, FW
    [J]. AUSTRALIAN JOURNAL OF CHEMISTRY, 1953, 6 (04) : 360 - 368
  • [10] A chain initiation factor common to both modular and aromatic polyketide synthases
    Bisang, C
    Long, PF
    Cortés, J
    Westcott, J
    Crosby, J
    Matharu, AL
    Cox, RJ
    Simpson, TJ
    Staunton, J
    Leadlay, PF
    [J]. NATURE, 1999, 401 (6752) : 502 - 505
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