Cdc42 - A signal coordinator in hematopoietic stem cell maintenance

被引：0

作者：

Yang, Linda ^{[1
]}

Zheng, Yi ^{[1
]}

机构：

[1] Univ Cincinnati, Childrens Hosp, Res Fdn, Div Expt Hematol, Cincinnati, OH 45229 USA

来源：

CELL CYCLE | 2007年 / 6卷 / 12期

关键词：

Rho GTPases; Cdc42; hematopoietic stem; cells; cell cycle; bone marrow niche;

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Maintenance of a relatively quiescent cell cycle state is a distinct characteristic of adult hematopoietic stem cells (HSCs) residing in the bone marrow ( BM) microenvironment. This property is considered critical for HSCs to fulfill long term self-renewal and multi lineage differentiation potential throughout mammalian life span. To date, the mechanisms regulating the cell cycle state and the retention of HSCs in the BM microenvironment remain unclear. Cdc42, a small GTPase of the Rho family known to control various cellular functions including adhesion, migration, transcription, and growth, is shown recently in a conditional gene-targeted mouse model to coordinate HSC quiescence maintenance and BM niche residency. The study also highlights a cell-type specific role of Cdc42 in cell cycle regulation.

引用

页码：1445 / 1450

页数：6

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