Treatment-related myelodysplasia following fludarabine combination chemotherapy

被引：1

作者：

Tam, Constantine S. ^{[1
,2
]}

Seymour, John F. ^{[1
,3
]}

Prince, H. Miles ^{[1
]}

Kenealy, Melita ^{[1
]}

Wolf, Max ^{[1
]}

Januszewicz, E. Henry ^{[1
]}

Westerman, David ^{[1
,4
]}

机构：

[1] Peter MacCallum Canc Ctr, Haematol Dept, Locked Bag 1,ABeckett St, Melbourne, Vic 8006, Australia

[2] Alfred Hosp, Haematol Dept, Melbourne, Australia

[3] Univ Melbourne, Melbourne, Australia

[4] Peter MacCallum Canc Ctr, Pathol Dept, Melbourne, Australia

来源：

HAEMATOLOGICA | 2006年 / 91卷 / 11期

关键词：

purine analog; chemoimmunotherapy; chronic lymphocytic leukemia; follicular lymphoma; Waldenstrom's macroglobulinemia;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Although myelodysplasia (MDS) and secondary acute myeloid leukemia (sAML) are rare following fludarabine monotherapy, the risk of these diseases may potentially be increased when fludarabine is combined with cyclophosphamide or mitoxantrone due to synergistic effects on the inhibition of DNA repair. Among 137 patients treated with fludarabine combination regimens, ten patients developed MDS/sAML, including one who had received no other therapy. Six patients had abnormalities of chromosomes 5 and/or 7. The crude rate of MDS/sAML was 2.5% for previously untreated patients, and 9.3% for pretreated patients (p=0.28). The rate of MDS/sAML following fludarabine combination therapy is higher than that previously reported for fludarabine monotherapy.

引用

页码：1546 / 1550

页数：5

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