Clinical Recommendation on Fertility Preservation in Borderline Ovarian Neoplasm: Ovarian Stimulation and Oocyte Retrieval after Conservative Surgery

被引:27
作者
Denschlag, Dominik [1 ]
von Wolff, Michael
Amant, Frederic
Kesic, Vesna
Reed, Nicholas
Schneider, Achim
Rodolakis, Alexandros
机构
[1] Univ Freiburg, Sch Med, Dept Obstet & Gynecol, DE-79106 Freiburg, Germany
关键词
Tumor; borderline; Neoplasm; ovarian; Ovarian stimulation; Oocyte retrieval; INFERTILITY TREATMENT; VITRO FERTILIZATION; TUMORS; MANAGEMENT; WOMEN; INDUCTION; CARCINOMA; OVULATION; OUTCOMES; CANCER;
D O I
10.1159/000316264
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Aim: To evaluate safety and fertility outcome after assisted conception in patients who were treated conservatively for a borderline ovarian tumor (BOT). Methods: A systematic literature review using Medline was conducted. From all the relevant case series the following information was obtained for each reported patient: primary diagnosis; disease stage; surgical treatment; duration of follow-up; incidence of recurrence; current disease status; the number of controlled ovarian stimulation cycles and/or oocyte retrievals, and successful pregnancies. Results: Overall 588 articles were screened, of which finally 15 reports including 62 patients met the inclusion criteria. Within a median follow-up duration of 52 months in this small group of patients, overall 12 patients (19.4%) had recurrences, and those recurrences were again successfully treated by surgery in 11 patients. In terms of assisted reproductive outcome, in our series overall 152 ovarian stimulation cycles as well as 135 oocyte retrievals were performed with a baby-take-home rate of 28.3% per stimulated cycle. Conclusion: It is mandatory to counsel all patients with a history of BOT who are seeking treatment for infertility that, due to the limited data, it is unclear whether assisted reproductive techniques are associated with an increased risk of recurrence. Copyright (C) 2010 S. Karger AG, Basel
引用
收藏
页码:160 / 165
页数:6
相关论文
共 34 条
  • [21] Borderline tumours of the ovary and fertility
    Morice, P
    [J]. EUROPEAN JOURNAL OF CANCER, 2006, 42 (02) : 149 - 158
  • [22] Ovarian stimulation and borderline ovarian tumors: a case-control study
    Mosgaard, BJ
    Lidegaard, O
    Kjaer, SK
    Schou, G
    Andersen, AN
    [J]. FERTILITY AND STERILITY, 1998, 70 (06) : 1049 - 1055
  • [23] BORDERLINE MALIGNANCY OF THE OVARY AND CONTROLLED HYPERSTIMULATION, A REPORT OF 2 CASES
    NIJMAN, HW
    BURGER, CW
    BAAK, JPA
    SCHATS, R
    VERMORKEN, JB
    KENEMANS, P
    [J]. EUROPEAN JOURNAL OF CANCER, 1992, 28A (12) : 1971 - 1973
  • [24] Treatment for fertility and risk of ovarian tumors of borderline malignancy
    Parazzini, F
    Negri, E
    La Vecchia, C
    Moroni, S
    Polatti, A
    Chiaffarino, F
    Surace, M
    Ricci, E
    [J]. GYNECOLOGIC ONCOLOGY, 1998, 68 (03) : 226 - 228
  • [25] Outcomes of controlled ovarian hyperstimulation/in vitro fertilization for infertile patients with borderline ovarian tumor after conservative treatment
    Park, Chan Woo
    Yang, Kwang Moon
    Kim, Hye Ok
    Hong, Sung Ran
    Kim, Tae Jin
    Lim, Kyung Taek
    Lee, Ki Heon
    Kang, Inn Soo
    [J]. JOURNAL OF KOREAN MEDICAL SCIENCE, 2007, 22 : S134 - S138
  • [26] Pecorelli S., 1998, J Epidemiol Biostat, V3, P75
  • [27] Healthy twins delivered after oocyte cryopreservation and bilateral ovariectomy for ovarian cancer
    Porcu, E.
    Venturoli, S.
    Damiano, G.
    Ciotti, P. M.
    Notarangelo, L.
    Paradis, R.
    Moscarini, M.
    Ambrosini, G.
    [J]. REPRODUCTIVE BIOMEDICINE ONLINE, 2008, 17 (02) : 265 - 267
  • [28] Induction of ovulation and borderline ovarian cancer - the hormonal connection?
    Shushan, A
    Paltiel, O
    Schenker, JG
    [J]. EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 1999, 85 (01): : 71 - 74
  • [29] Assisted reproduction in patients with early-stage ovarian malignancies
    Steinkampf, MP
    Dharia, SP
    Hammond, K
    [J]. FERTILITY AND STERILITY, 2003, 80 (06) : 1510 - 1512
  • [30] Long-term outcomes following conservative surgery for borderline tumor of the ovary: A large population-based study
    Suh-Burgmann, Elizabeth
    [J]. GYNECOLOGIC ONCOLOGY, 2006, 103 (03) : 841 - 847