Identification of Imaging Predictors Discriminating Different Primary Liver Tumours in Patients with Chronic Liver Disease on Gadoxetic Acid-enhanced MRI: a Classification Tree Analysis

被引:29
|
作者
Park, Hyun Jeong [1 ]
Jang, Kyung Mi [2 ,3 ]
Kang, Tae Wook [2 ,3 ]
Song, Kyoung Doo [2 ,3 ]
Kim, Seong Hyun [2 ,3 ]
Kim, Young Kon [2 ,3 ]
Cha, Dong Ik [2 ,3 ]
Kim, Joungyoun [4 ]
Goo, Juna [4 ]
机构
[1] Chung Ang Univ, Chung Ang Univ Hosp, Dept Radiol, Coll Med, 102 Heukseok Ro, Seoul 156755, South Korea
[2] Sungkyunkwan Univ, Dept Radiol, Samsung Med Ctr, Sch Med, Seoul, South Korea
[3] Sungkyunkwan Univ, Ctr Imaging Sci, Samsung Med Ctr, Sch Med, Seoul, South Korea
[4] Sungkyunkwan Univ, Biostat & Clin Epidemiol Ctr, Samsung Med Ctr, Sch Med, Seoul, South Korea
关键词
Hepatocellular carcinoma; Cholangiocarcinoma; Combined hepatocellular-cholangiocarcinoma; Gadoxetic acid; Classification tree analysis; CHOLANGIOCARCINOMA CLINICAL-FEATURES; HEPATOCELLULAR-CARCINOMA; INTRAHEPATIC CHOLANGIOCARCINOMA; HISTOLOGIC CORRELATION; PATTERNS; IMAGES; CIRRHOSIS; HEPATITIS; CANCER; MODEL;
D O I
10.1007/s00330-015-4136-y
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
To identify predictors for the discrimination of intrahepatic cholangiocarcinoma (IMCC) and combined hepatocellular-cholangiocarcinoma (CHC) from hepatocellular carcinoma (HCC) for primary liver cancers on gadoxetic acid-enhanced MRI among high-risk chronic liver disease (CLD) patients using classification tree analysis (CTA). A total of 152 patients with histopathologically proven IMCC (n = 40), CHC (n = 24) and HCC (n = 91) were enrolled. Tumour marker and MRI variables including morphologic features, signal intensity, and enhancement pattern were used to identify tumours suspicious for IMCC and CHC using CTA. On CTA, arterial rim enhancement (ARE) was the initial splitting predictor for assessing the probability of tumours being IMCC or CHC. Of 43 tumours that were classified in a subgroup on CTA based on the presence of ARE, non-intralesional fat, and non-globular shape, 41 (95.3 %) were IMCCs (n = 29) or CHCs (n = 12). All 24 tumours showing fat on MRI were HCCs. The CTA model demonstrated sensitivity of 84.4 %, specificity of 97.8 %, and accuracy of 92.3 % for discriminating IMCCs and CHCs from HCCs. We established a simple CTA model for classifying a high-risk group of CLD patients with IMCC and CHC. This model may be useful for guiding diagnosis for primary liver cancers in patients with CLD. aEuro cent Arterial rim enhancement was the initial splitting predictor on CTA. aEuro cent CTA model achieved high sensitivity, specificity, and accuracy for discrimination of tumours. aEuro cent This model may be useful for guiding diagnosis of primary liver cancers.
引用
收藏
页码:3102 / 3111
页数:10
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