The impact of alpha-lipoic acid on amikacin-induced nephrotoxicity

被引:11
作者
Asci, Halil [1 ]
Saygin, Mustafa [2 ]
Cankara, Fatma Nihan [1 ]
Bayram, Dilek [3 ]
Yesilot, Sukriye [1 ]
Candan, Ibrahim Aydin [3 ]
Ilhan, Ilter [4 ]
机构
[1] Suleyman Demirel Univ, Fac Med, Dept Pharmacol, TR-32260 Isparta, Turkey
[2] Suleyman Demirel Univ, Fac Med, Dept Physiol, TR-32260 Isparta, Turkey
[3] Suleyman Demirel Univ, Fac Med, Dept Histol & Embryol, TR-32260 Isparta, Turkey
[4] Suleyman Demirel Univ, Fac Med, Dept Biochem, TR-32260 Isparta, Turkey
关键词
Amikacin; alpha lipoic acid; nephrotoxicity; oxidative damage; renal failure; CISPLATIN-INDUCED NEPHROTOXICITY; OXIDATIVE STRESS; PROTECTIVE ROLE; RENAL ISCHEMIA; INJURY; AMINOGLYCOSIDES; INACTIVATION; KIDNEY; DAMAGE; RATS;
D O I
10.3109/0886022X.2014.967645
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Amikacin (AK) is an antibacterial drug, but it has remarkable nephrotoxic and ototoxic side effects due to increase in reactive oxygen radicals. This study was established to determine the possible protective effects of alpha-lipoic acid (ALA), a powerful antioxidant, on AK-induced nephrotoxicity. Three different groups of rats (n = 6) were administered saline (control), AK (1.2 g/kg, intraperitoneally), ALA (100 mg/kg, p.o.) and AK combination (ALA one day before the AK for five days). Renal function, oxidative stress markers and histological changes were evaluated at the end of the experiment. Malondialdehyde was increased as an indicator of free radical formation in AK-induced group and decreased with ALA treatment. While catalase activity was increased significantly, superoxide dismutase and glutathione peroxidase activities were not statistically significant increased with ALA treatment. The result showed that AK enhanced levels of urea, creatinine and blood urea nitrogen in serum significantly. Administration of ALA reduced these levels of biochemical markers. Histopathological observations were confirmed by biochemical findings. In conclusion, ALA is suggested to be a potential candidate to ameliorate AK-induced nephrotoxicity.
引用
收藏
页码:117 / 121
页数:5
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