Renal blood flow and acute kidney injury in septic shock: an arduous conflict that smolders intrarenally?

被引：19
作者：
Honore, Patrick M. [1 ]
Jacobs, Rita [1 ]
De Waele, Elisabeth [1 ]
Diltoer, Marc [1 ]
Spapen, Herbert D. [1 ]
机构：
[1] Vrije Univ Brussel, Univ Ziekenhuis Brussel, Intens Care Unit Dept, 101 Laarbeeklaan, B-1090 Brussels, Belgium
来源：
KIDNEY INTERNATIONAL | 2016年 / 90卷 / 01期
关键词：
SEPSIS; PATHOPHYSIOLOGY;
D O I：
10.1016/j.kint.2016.03.025
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Sepsis-induced acute kidney injury (SAKI) is traditionally viewed as a process driven by a reduced blood flow and prone to benefit from vasopressive support. In ovine hyperdynamic septic shock, Lankadeva et al. report a significant and flow-independent intrarenal perfusion and oxygenation "mismatch" jeopardizing the renal medulla that was aggravated by norepinephrine. Medullary and urinary oxygenation changed in parallel, suggesting that urinary oxygenation may act as a biomarker to predict SAKI.
引用
收藏
页码：22 / 24
页数：4
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