Synthesis of 4-(2-(piperazin-1-yl)-7,8-dihydro-5H-thiopyrano[4,3-d] pyrimidin-4-yl)morpholine and 4-morpholino-2-(piperazin-1-yl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine 6,6-dioxide

被引：1

作者：

Xu, Shan ^{[1
]}

Sun, Chengyu ^{[1
]}

Lei, Fei ^{[1
]}

Tu, Yuanbiao ^{[1
]}

Zeng, Weipeng ^{[1
]}

Xia, Hui ^{[1
]}

Zheng, Pengwu ^{[1
]}

Zhu, Wufu ^{[1
]}

机构：

[1] Jiangxi Sci & Technol Normal Univ, Sch Pharm, Nanchang 330013, Peoples R China

来源：

MATERIAL SCIENCE, CIVIL ENGINEERING AND ARCHITECTURE SCIENCE, MECHANICAL ENGINEERING AND MANUFACTURING TECHNOLOGY II | 2014年 / 651-653卷

关键词：

PI3K/mTOR ihhibitors; Thiopyrano[4,3-d]pyrimidine derivatives; Synthesis;

D O I：

10.4028/www.scientific.net/AMM.651-653.111

中图分类号：

TU [建筑科学];

学科分类号：

0813 ;

摘要：

Two novel thiopyrano[4,3-d]pyrimidine derivatives 7 and 8 were synthesized from dimethyl 3,3'-thiodipropanoate through six steps including two times of cyclization, chlorination, oxidation, substitution with morpholine and piperazine and their structures were confirmed by H-1 NMR and MS spectrum. The total yield of the six steps was 18.6% (calculated from methyl dimethyl 3,3'-thiodipropanoate). The synthetic routes of them can be used to synthesize PI3K/mTOR inhibitors bearing a thiopyrano[4,3-d] pyrimidine nucleus.

引用

页码：111 / 114

页数：4

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