Octahedral ruthenium complexes selectively stabilize G-quadruplexes

被引：22
作者：
He, Lei [1 ]
Chen, Xiang [1 ]
Meng, Zhenyu [1 ]
Wang, Jintao [1 ]
Tian, Keyin [1 ]
Li, Tianhu [1 ]
Shao, Fangwei [1 ]
机构：
[1] Nanyang Technol Univ, Div Chem & Biol Chem, Sch Phys & Math Sci, Singapore 637371, Singapore
来源：
CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 52期
关键词：
HUMAN TELOMERIC SEQUENCE; CRYSTAL-STRUCTURE; DNA; BINDING;
D O I：
10.1039/c6cc03117j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of octahedral Ru(II) complexes with an x-y planar tetradentate and two trans-z-axis ammonia ligands were synthesized. High stabilization of G-quadruplexes was achieved upon p-stacking with aromatic planar ligands. Unique interaction from z-axis ligands bestowed both excellent binding resistance to duplex DNA and selectivity towards the antiparallel topology.
引用
收藏
页码：8095 / 8098
页数：4
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共 25 条
  • [1] Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution
    Ambrus, Attila
    Chen, Ding
    Dai, Jixun
    Bialis, Tiffanie
    Jones, Roger A.
    Yang, Danzhou
    [J]. NUCLEIC ACIDS RESEARCH, 2006, 34 (09) : 2723 - 2735
  • [2] Porphyrin binding to quadruplexed T4G4
    Anantha, NV
    Azam, M
    Sheardy, RD
    [J]. BIOCHEMISTRY, 1998, 37 (09) : 2709 - 2714
  • [3] Induction of G-quadruplex DNA structure by Zn(II) 5,10,15,20-tetrakis (N-methyl-4-pyridyl)porphyrin
    Bhattacharjee, Amlan J.
    Ahluwalia, Karan
    Taylor, Scott
    Jin, Ou
    Nicoludis, John M.
    Buscaglia, Robert
    Chaires, J. Brad
    Kornfilt, David J. P.
    Marquardt, David G. S.
    Yatsunyk, Liliya A.
    [J]. BIOCHIMIE, 2011, 93 (08) : 1297 - 1309
  • [4] DNA secondary structures: stability and function of G-quadruplex structures
    Bochman, Matthew L.
    Paeschke, Katrin
    Zakian, Virginia A.
    [J]. NATURE REVIEWS GENETICS, 2012, 13 (11) : 770 - 780
  • [5] Solution Structure of a G-quadruplex Bound to the Bisquinolinium Compound Phen-DC3
    Chung, Wan Jun
    Heddi, Brahim
    Hamon, Florian
    Teulade-Fichou, Marie-Paule
    Anh Tuan Phan
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2014, 53 (04) : 999 - 1002
  • [6] A G-quadruplex ligand with 10000-fold selectivity over duplex DNA
    Dixon, Isabelle M.
    Lopez, Frederic
    Tejera, Agueda M.
    Esteve, Jean-Pierre
    Blasco, Maria A.
    Pratviel, Genevieve
    Meunier, Bernard
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (06) : 1502 - +
  • [7] Towards the Development of Structure-Selective G-Quadruplex-Binding Indolo[3,2-b]quinolines
    Funke, Andrea
    Dickerhoff, Jonathan
    Weisz, Klaus
    [J]. CHEMISTRY-A EUROPEAN JOURNAL, 2016, 22 (09) : 3170 - 3181
  • [8] Interaction of Metal Complexes with G-Quadruplex DNA
    Georgiades, Savvas N.
    Abd Karim, Nurul H.
    Suntharalingam, Kogularamanan
    Vilar, Ramon
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (24) : 4020 - 4034
  • [9] 4-STRANDED NUCLEIC-ACID STRUCTURES 25 YEARS LATER - FROM GUANOSINE GELS TO TELOMER DNA
    GUSCHLBAUER, W
    CHANTOT, JF
    THIELE, D
    [J]. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 1990, 8 (03) : 491 - 511
  • [10] Quadruplex Turncoats: Cation-Dependent Folding and Stability of Quadruplex-DNA Double Switches
    Largy, Eric
    Marchand, Adrien
    Amrane, Samir
    Gabelica, Valerie
    Mergny, Jean-Louis
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2016, 138 (08) : 2780 - 2792
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