Roles of Regulatory T Cells in Tissue Pathophysiology and Metabolism

被引：113

作者：

Campbell, Clarissa ^{[1
,2
,3
]}

Rudensky, Alexander ^{[1
,2
,3
,4
]}

机构：

[1] Howard Hughes Med Inst, New York, NY 10065 USA

[2] Sloan Kettering Inst, Immunol Program, New York, NY 10065 USA

[3] Mem Sloan Kettering Canc Ctr, Ludwig Ctr, New York, NY 10065 USA

[4] Weill Cornell Grad Sch Med Sci, Immunol & Microbial Pathogenesis Program, New York, NY 10021 USA

来源：

CELL METABOLISM | 2020年 / 31卷 / 01期

关键词：

IMMUNE PRIVILEGE; ADIPOSE-TISSUE; GENE; TOLERANCE; MICE; DIFFERENTIATION; ACCUMULATION; INFLAMMATION; POPULATION; DEPLETION;

D O I：

10.1016/j.cmet.2019.09.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Regulatory T (Treg) cells expressing the X-chromosome-encoded transcription factor Foxp3 represent a specialized immunosuppressive lineage with a well-recognized, essential function in preventing fatal autoimmunity and inflammation. Recent studies revealed that Treg cells can also exert systemic effects on metabolism and partake in tissue repair, suggesting a dual role for these cell in serving and protecting tissue Here, we review multiple means by which Treg cells support tissue function and organismal homeostasis.

引用

页码：18 / 25

页数：8

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