Influence of Controlled Fluid Shear on Nucleation Rates in Glycine Aqueous Solutions

被引：61

作者：

Forsyth, Carol ^{[1
]}

Mulheran, Paul A. ^{[1
]}

Forsyth, Claire ^{[1
]}

Haw, Mark D. ^{[1
]}

Burns, Iain S. ^{[1
]}

Sefcik, Jan ^{[1
]}

机构：

[1] Univ Strathclyde, Dept Chem & Proc Engn, Glasgow G1 1XJ, Lanark, Scotland

来源：

CRYSTAL GROWTH & DESIGN | 2015年 / 15卷 / 01期

关键词：

MECHANICAL STIMULUS; INDUCED ORDER; CRYSTALLIZATION; CRYSTALS; GROWTH; KINETICS; FLOW;

D O I：

10.1021/cg5008878

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The nucleation of glycine was investigated in supersaturated aqueous solutions exposed to well-controlled fluid shear under isothermal conditions. Shear rates between 25 s(-1) and 1000 s(-1) were studied using Couette and capillary flow devices. Induction times were obtained from imaging, transmission and scattering measurements, or visual monitoring. Great care was taken to eliminate any seeding in order to avoid secondary nucleation preceding formation of first crystals through primary nucleation. The observed induction times of sheared solutions were considerably lower than those of unsheared solutions. Increasing the average shear rate was found to reduce the mean induction time through a power law relationship. A detailed statistical analysis showed that the number of experimental repetitions used was sufficient to obtain statistically significant trends for the system studied. Induction times appeared to closely follow a probability distribution based on a previously published model of Jiang and ter Horst. Using their model, where the induction time is related to the rate of formation of primary nuclei and the time it takes them to grow to the size where the secondary nucleation becomes significant, it was found that both the primary nucleation rate and the growth time were strongly dependent on the shear rate imposed.

引用

页码：94 / 102

页数：9

共 46 条

[1] SHEAR-INDUCED ORDER IN SUSPENSIONS OF HARD-SPHERES [J].

ACKERSON, BJ ;

PUSEY, PN .

PHYSICAL REVIEW LETTERS, 1988, 61 (08) :1033-1036

[2] Fabrication of large-area face-centered-cubic hard-sphere colloidal crystals by shear alignment [J].

Amos, RM ;

Rarity, JG ;

Tapster, PR ;

Shepherd, TJ ;

Kitson, SC .

PHYSICAL REVIEW E, 2000, 61 (03) :2929-2935

[3]

Berkeley, 1912, PHILOS MAG, V24, P254

[4] Homogeneous nucleation of colloidal melts under the influence of shearing fields [J].

Blaak, R ;

Auer, S ;

Frenkel, D ;

Löwen, H .

JOURNAL OF PHYSICS-CONDENSED MATTER, 2004, 16 (38) :S3873-S3884

[5] KINETICS OF CRYSTALLIZATION IN A SHEARING COLLOIDAL SUSPENSION [J].

BUTLER, S ;

HARROWELL, P .

PHYSICAL REVIEW E, 1995, 52 (06) :6424-6430

[6] Using microfluidics to observe the effect of mixing on nucleation of protein crystals [J].

Chen, DL ;

Gerdts, CJ ;

Ismagilov, RF .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (27) :9672-9673

[7] PRELIMINARY INVESTIGATIONS OF PROTEIN CRYSTAL-GROWTH USING THE SPACE-SHUTTLE [J].

DELUCAS, LJ ;

SUDDATH, FL ;

SNYDER, R ;

NAUMANN, R ;

BROOM, MB ;

PUSEY, M ;

YOST, V ;

HERREN, B ;

CARTER, D ;

NELSON, B ;

MEEHAN, EJ ;

MCPHERSON, A ;

BUGG, CE .

JOURNAL OF CRYSTAL GROWTH, 1986, 76 (03) :681-693

[8] VISCOSITY B-COEFFICIENTS AT 15 AND 25 DEGREES C FOR GLYCINE, BETA-ALANINE, 4-AMINO-BUTYRIC ACID, AND 6-AMINO-HEXANOIC ACID IN AQUEOUS SOLUTION [J].

DEVINE, W ;

LOWE, BM .

JOURNAL OF THE CHEMICAL SOCIETY A -INORGANIC PHYSICAL THEORETICAL, 1971, (13) :2113-&

[9] Acceleration of crystal growth rates: an unexpected effect of tailor-made additives [J].

Dowling, Richard ;

Davey, Roger J. ;

Curtis, Robin A. ;

Han, Guangjun ;

Poornachary, Sendhil K. ;

Chow, Pui Shan ;

Tan, Reginald B. H. .

CHEMICAL COMMUNICATIONS, 2010, 46 (32) :5924-5926

[10] Nucleation of Crystals from Solution: Classical and Two-Step Models [J].

Erdemir, Deniz ;

Lee, Alfred Y. ;

Myerson, Allan S. .

ACCOUNTS OF CHEMICAL RESEARCH, 2009, 42 (05) :621-629

← 1 2 3 4 5 →