Irradiation of myxoid/round cell liposarcoma induces volume reduction and lipoma-like morphology

被引:51
作者
Engstrom, Katarina
Bergh, Peter
Cederlund, Claes-Goran
Hultborn, Ragnar [1 ]
Willen, Helena
Aman, Pierre
Kindblom, Lars-Gunnar
Meis-Kindblom, Jeanne M.
机构
[1] Sahlgrens Univ Hosp, Dept Oncol, S-41345 Gothenburg, Sweden
[2] Sahlgrens Univ Hosp, Dept Orthopaed, S-41345 Gothenburg, Sweden
[3] Sahlgrens Univ Hosp, Dept Diagnost Radiol, S-41345 Gothenburg, Sweden
[4] Sahlgrens Univ Hosp, Dept Pathol, Lundberg Lab Canc Res, Gothenburg, Sweden
关键词
D O I
10.1080/02841860601080415
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The aim of the study was to investigate the clinical and morphological effects of radiotherapy in the treatment of myxoid/round cell liposarcoma (MLS/RCLS). Thirty-three primary and metastatic MLS/RCLS tumours in 15 patients were treated with radiation therapy. Twenty-seven of the 33 tumours were surgically removed after preoperative radiation (34-46 Gy) while six tumours were treated with radiotherapy alone (44-60 Gy). The pretreatment diagnosis was established in all 15 patients based on fine needle aspirates or histological findings. Tumour size was measured by CT or MRI before and after radiotherapy in 30 tumours. Thirteen tumours from 11 patients were genetically characterised before and/or after radiation therapy. Twenty-three of 30 irradiated tumours showed a median reduction in tumour volume of 52% and seven lesions a median progression of 36%. All 27 surgically removed tumours revealed histological features of radiation response. The most striking morphological changes were lipoma-like appearance, paucicellularity and hyalinisation. Twelve of 13 tumours analysed before and/or after radiation therapy showed the FUS-DDIT3 translocation. Radiation therapy of MLS/RCLS induces histopathologic accumulation of mature lipoma-like areas and tumour volume reduction that may facilitate resectability. © 2007 Taylor & Francis.
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收藏
页码:838 / 845
页数:8
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