A simple, rapid method for the preparation of [11C]formaldehyde

被引：41

作者：

Hooker, Jacob M. ^{[1
]}

Schoenberger, Matthias ^{[2
]}

Schieferstein, Hanno ^{[2
]}

Fowler, Joanna S. ^{[1
,3
,4
]}

机构：

[1] Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA

[2] Johannes Gutenberg Univ Mainz, Mainz, Germany

[3] SUNY Stony Brook, Stony Brook, NY USA

[4] Mt Sinai Sch Med, New York, NY USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 32期

关键词：

formaldehyde; isotopic labeling; N-oxides; oxidation; positron emission tomography;

D O I：

10.1002/anie.200800991

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A PET project: A powerful reagent for the synthesis of positron-emitting imaging molecules - [11C]formaldehyde - is accessible from [ 11C]methyl iodide and trimethylamine N-oxide (TMAO) in high yields and under mild conditions. Easy access to [11C]formaldehyde expands the scope of the carbon-11 toolbox and will lead to new reaction methodology and imaging compounds. (Chemical Equation Presented). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

收藏

页码：5989 / 5992

页数：4

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