Regulation of innate immunity by Nrf2

被引：41

作者：

van der Horst, D. ^{[1
]}

Carter-Timofte, M. E. ^{[1
]}

van Grevenynghe, J. ^{[2
]}

Laguette, N. ^{[3
]}

Dinkova-Kostova, A. T. ^{[4
,5
,6
]}

Olagnier, D. ^{[1
]}

机构：

[1] Aarhus Univ, Dept Biomed, Aarhus, Denmark

[2] Inst Natl Rech Sci INRS, Ctr Armand Frappier Sante Biotechnol, Laval, PQ, Canada

[3] Univ Montpellier, Inst Genet Humaine, CNRS, Montpellier, France

[4] Univ Dundee, Jacqui Wood Canc Ctr, Sch Med, Div Cellular Med, Dundee, Scotland

[5] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD USA

[6] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2022年 / 78卷

关键词：

NF-KAPPA-B; FACTOR-2; NRF2; KEAP1; ACTIVATION; PATHWAY; PROTEIN; NLRP3; RECRUITMENT; ITACONATE; INTERLEUKIN-17D;

D O I：

10.1016/j.coi.2022.102247

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2) has been mainly investigated as a regulator of redox homeostasis. However, research over the past years has implicated Nrf2 as an important regulator of innate immunity. Here, we discuss the role of Nrf2 in the innate immune response, highlighting the interaction between Nrf2 and major components of the innate immune system. Indeed, Nrf2 has been shown to widely control the immune response by interacting directly or indirectly with important innate immune components, including the toll-like receptors-Nuclear factor kappa B (NF-kB) pathway, inflammasome signaling, and the type-I interferon response. This indicates an essential role for Nrf2 in diseases related to microbial infections, inflammation, and cancer. Yet, further studies are required to determine the exact mechanism underpinning the interactions between Nrf2 and innate immune players in order to allow a better understanding of these diseases and leverage new therapeutic strategies.

引用

页数：7