Exploring the Relationship of Perivascular Adipose Tissue Inflammation and the Development of Vascular Pathologies

被引：24

作者：

Rami, Afifah Zahirah Abd ^{[1
]}

Hamid, Adila A. ^{[1
]}

Anuar, Nur Najmi Mohamad ^{[2
]}

Aminuddin, Amilia ^{[1
]}

Ugusman, Azizah ^{[1
]}

机构：

[1] Univ Kebangsaan Malaysia, Dept Physiol, Fac Med, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia

[2] Univ Kebangsaan Malaysia, Ctr Toxicol & Hlth Risk Studies, Fac Hlth Sci, Jalan Raja Muda Abd Aziz, Kuala Lumpur 50300, Malaysia

来源：

MEDIATORS OF INFLAMMATION | 2022年 / 2022卷

关键词：

NITRIC-OXIDE SYNTHASE; GROWTH-FACTOR; 21; MONOCYTE CHEMOATTRACTANT PROTEIN-1; SMOOTH-MUSCLE-CELLS; NF-KAPPA-B; OXIDATIVE STRESS; T-CELLS; ENDOTHELIAL DYSFUNCTION; CHEMOKINE RANTES; INTERFERON-GAMMA;

D O I：

10.1155/2022/2734321

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Initially thought to only provide mechanical support for the underlying blood vessels, perivascular adipose tissue (PVAT) has now emerged as a regulator of vascular function. A healthy PVAT exerts anticontractile and anti-inflammatory actions on the underlying vasculature via the release of adipocytokines such as adiponectin, nitric oxide, and omentin. However, dysfunctional PVAT produces more proinflammatory adipocytokines such as leptin, resistin, interleukin- (IL-) 6, IL-1 beta, and tumor necrosis factor-alpha, thus inducing an inflammatory response that contributes to the pathogenesis of vascular diseases. In this review, current knowledge on the role of PVAT inflammation in the development of vascular pathologies such as atherosclerosis and hypertension was discussed.

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页数：16

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