ROS signaling and redox biology in endothelial cells

被引：111
|
作者：
Panieri, Emiliano [1 ]
Santoro, Massimo M. [2 ,3 ]
机构：
[1] Univ Turin, Ctr Mol Biotechnol, Dept Mol Biotechnol & Hlth Sci, Turin, Italy
[2] VIB, Vesalius Res Ctr, Lab Endothelial Mol Biol, B-3000 Leuven, Belgium
[3] Univ Leuven, Dept Oncol, Lab Endothelial Mol Biol, B-3000 Leuven, Belgium
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2015年 / 72卷 / 17期
关键词：
Reactive Oxygen Species; Redox signaling; Angiogenesis; Genetically-encoded sensors; Redox compartmentalization; Pathological angiogenesis; NF-KAPPA-B; GROWTH-FACTOR-RECEPTOR; NITRIC-OXIDE SYNTHASE; PROTEIN-TYROSINE PHOSPHATASES; IMAGING HYDROGEN-PEROXIDE; SULFENIC ACID FORMATION; AKT/PROTEIN KINASE-B; REACTIVE OXYGEN; NADPH-OXIDASE; OXIDATIVE STRESS;
D O I：
10.1007/s00018-015-1928-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The purpose of this review is to provide an overview of redox mechanisms, sources and antioxidants that control signaling events in ECs. In particular, we describe which molecules are involved in redox signaling and how they influence the relationship between ECs and other vascular component with regard to angiogenesis. Recent and new tools to investigate physiological ROS signaling will be also discussed. Such findings are providing an overview of the ROS biology relevant for endothelial cells in the context of normal and pathological angiogenic conditions.
引用
收藏
页码：3281 / 3303
页数：23
相关论文
共 50 条
  • [41] (+)-Aeroplysinin-1 Modulates the Redox Balance of Endothelial Cells
    Garcia-Vilas, Javier A.
    Martinez-Poveda, Beatriz
    Quesada, Ana R.
    Angel Medina, Miguel
    MARINE DRUGS, 2018, 16 (09):
  • [42] Compartmentalization of Redox Signaling Through NADPH Oxidase-Derived ROS
    Ushio-Fukai, Masuko
    ANTIOXIDANTS & REDOX SIGNALING, 2009, 11 (06) : 1289 - 1299
  • [43] Cross-Talk between NADPH Oxidase and Mitochondria: Role in ROS Signaling and Angiogenesis
    Fukai, Tohru
    Ushio-Fukai, Masuko
    CELLS, 2020, 9 (08)
  • [44] Hypoxia-Induced Mitochondrial ROS and Function in Pulmonary Arterial Endothelial Cells
    Wang, Harrison
    Song, Teng-Yao
    Reyes-Garcia, Jorge
    Wang, Yong-Xiao
    CELLS, 2024, 13 (21)
  • [45] The Role of Hydrogen Peroxide in Redox-Dependent Signaling: Homeostatic and Pathological Responses in Mammalian Cells
    Di Marzo, Noemi
    Chisci, Elisa
    Giovannoni, Roberto
    CELLS, 2018, 7 (10)
  • [46] Endothelial Cell Redox Regulation of Ischemic Angiogenesis
    Cohen, Richard A.
    Murdoch, Colin E.
    Watanabe, Yosuke
    Bolotina, Victoria M.
    Evangelista, Alicia M.
    Haeussler, Dagmar J.
    Smith, Melissa D.
    Mei, Yu
    Tong, XiaoYong
    Han, Jingyan
    Behring, Jessica B.
    Bachschmid, Markus M.
    Matsui, Reiko
    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2016, 67 (06) : 458 - 464
  • [47] Control of SUMO and Ubiquitin by ROS: Signaling and disease implications
    Stankovic-Valentin, Nicolas
    Melchior, Frauke
    MOLECULAR ASPECTS OF MEDICINE, 2018, 63 : 3 - 17
  • [48] Fibroblasts to Keratinocytes Redox Signaling: The Possible Role of ROS in Psoriatic Plaque Formation
    Barygina, Victoria
    Becatti, Matteo
    Prignano, Francesca
    Lotti, Torello
    Taddei, Niccolo
    Fiorillo, Claudia
    ANTIOXIDANTS, 2019, 8 (11)
  • [49] ROS Production and Scavenging under Anoxia and Re-Oxygenation in Arabidopsis Cells: A Balance between Redox Signaling and Impairment
    Paradiso, Annalisa
    Caretto, Sofia
    Leone, Antonella
    Bove, Anna
    Nisi, Rossella
    De Gara, Laura
    FRONTIERS IN PLANT SCIENCE, 2016, 7
  • [50] Redox Signaling and Regional Heterogeneity of Endothelial Dysfunction indb/dbMice
    Sallam, Nada A.
    Laher, Ismail
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (17) : 1 - 20
12345