The Role of Tec Family Kinases in the Regulation of T-helper-cell Differentiation

被引：15
|
作者：
Boucheron, Nicole [1 ]
Ellmeier, Wilfried [1 ]
机构：
[1] Med Univ Vienna, Inst Immunol, Div Immunobiol, Ctr Pathophysiol Infectiol & Immunol, A-1090 Vienna, Austria
来源：
INTERNATIONAL REVIEWS OF IMMUNOLOGY | 2012年 / 31卷 / 02期
基金：
奥地利科学基金会;
关键词：
CD4(+) T cells; immune regulation; protein tyrosine kinases; Th subsets; BRUTONS TYROSINE KINASE; X-LINKED AGAMMAGLOBULINEMIA; PLECKSTRIN HOMOLOGY DOMAIN; GAMMA GENE-TRANSCRIPTION; CYTOKINE PRODUCTION; MICE LACKING; SRC-FAMILY; IN-VIVO; PHOSPHATIDYLINOSITOL; 3-KINASE; LYMPHOCYTE DEVELOPMENT;
D O I：
10.3109/08830185.2012.664798
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Members of the Tec kinase family (Tec, Btk, Itk, Rlk, and Bmx) play an important role during innate and adaptive immune responses, and mutations in Tec family kinases are linked with immunodeficiencies in humans and mice. Three members of the Tec kinase family are expressed in T cells (Tec, Itk, and Rlk), and biochemical and genetic studies have revealed important roles for Tec family kinases during T-cell development and in the control of T-cell function. Here the authors review the role of Tec family kinases in the regulation of T-helper-cell differentiation.
引用
收藏
页码：133 / 154
页数：22
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