DJ-1 promotes cell proliferation and tumor metastasis in esophageal squamous cell carcinoma via the Wnt/β-catenin signaling pathway

被引：18

作者：

Jin, Feng ^{[1
]}

Wang, Haibo ^{[2
,3
]}

Li, Dan ^{[2
,3
]}

Fang, Chuanchi ^{[2
,3
]}

Li, Wenyuan ^{[2
,3
]}

Shi, Qingtong ^{[4
]}

Diao, Yali ^{[4
]}

Ding, Zhiyan ^{[5
]}

Dai, Xiaojun ^{[2
,3
,6
]}

Tao, Li ^{[2
,3
]}

Sunagawa, Masataka ^{[7
]}

Wu, Feng ^{[1
]}

Qian, Yayun ^{[2
,3
]}

Liu, Yanqing ^{[2
,3
]}

机构：

[1] Yangzhou Univ, Affiliated Hosp, Dept Resp Med, Yangzhou 225001, Jiangsu, Peoples R China

[2] Yangzhou Univ, Inst Combining Chinese Tradit & Western Med, Med Coll, 136 Jiangyang Middle Rd, Yangzhou 225009, Jiangsu, Peoples R China

[3] Yangzhou Univ, State Adm Tradit Chinese Med, Key Lab Tox Pathogens Based Therapeut Approaches, Yangzhou 225009, Jiangsu, Peoples R China

[4] Yangzhou Univ, Affiliated Hosp, Dept Thorac Surg, Yangzhou 225001, Jiangsu, Peoples R China

[5] Yangzhou Univ, Affiliated Hosp, Dept Pathol, Yangzhou 225001, Jiangsu, Peoples R China

[6] Yangzhou Tradit Chinese Med Hosp, Yangzhou 225009, Jiangsu, Peoples R China

[7] Showa Univ, Sch Med, Dept Physiol, Tokyo 1428555, Japan

来源：

INTERNATIONAL JOURNAL OF ONCOLOGY | 2020年 / 56卷 / 05期

基金：

中国国家自然科学基金;

关键词：

DJ-1; esophageal squamous cell carcinoma; cell proliferation; invasion; Wnt; beta-catenin signaling pathway; EPITHELIAL-MESENCHYMAL TRANSITION; HEPATOCELLULAR-CARCINOMA; CANCER PROGRESSION; REGULATOR; DISEASE; PROTEIN; LRP6; EMT;

D O I：

10.3892/ijo.2020.5005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

DJ-1, an oncogene, has been reported to be an independent prognostic indicator of poor survival in patients with esophageal squamous cell carcinoma (ESCC). The aim of the present study was to investigate the role of DJ-1 in tumor cell proliferation and invasion in ESCC and its underlying mechanisms. It was observed that the expression level of DJ-1 was upregulated and positively associated with EMT biomarkers in 84 human ESCC tissue specimens. Overexpression and knockdown experiments demonstrated that DJ-1 was involved in proliferation, migration, invasion and EMT in ECA-109 cells in vitro and extensive peritoneal seeding in a peritoneal dissemination mice model. Furthermore, the present data revealed that DJ-1 could activate the Wnt/beta-catenin signaling pathway, which mediates the EMT and metastasis in ESCC. In conclusions, DJ-1 promoted proliferation, invasion, metastasis and the EMT in ESCC via activation of the Wnt/beta-catenin signal pathway. The present results suggested DJ-1 could represent a promising therapeutic target for the prevention and treatment of ESCC-related metastasis.

引用

页码：1115 / 1128

页数：14

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