Distinguishing Non-Small Cell Lung Adenocarcinoma Patients from Squamous Cell Carcinoma Patients and Control Individuals Using Serum Profiling

被引：6

作者：

Hocker, James R. ^{[1
]}

Peyton, Marvin D. ^{[2
]}

Lerner, Megan R. ^{[2
,3
]}

Lightfoot, Stan A. ^{[3
,4
]}

Hanas, Rushie J. ^{[1
]}

Brackett, Daniel J. ^{[2
,3
]}

Hanas, Jay S. ^{[1
,2
,3
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Dept Biochem & Mol Biol, Oklahoma City, OK 73104 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Dept Surg, Oklahoma City, OK 73104 USA

[3] Vet Affairs Med Ctr, Oklahoma City, OK 73104 USA

[4] Univ Oklahoma, Hlth Sci Ctr, Dept Pathol, Oklahoma City, OK 73104 USA

来源：

CANCER INVESTIGATION | 2012年 / 30卷 / 02期

关键词：

Non-small cell lung cancer; Adenocarcinoma; Squamous cell carcinoma; Serum profiling; Early detection; Predictive value analysis; Electrospray mass spectrometry; OVARIAN-CANCER; IDENTIFICATION; SPECTROMETRY; BIOMARKERS; PROTEOMICS; DISCOVERY;

D O I：

10.3109/07357907.2011.633294

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Goals of this study were to analyze the ability of mass spectrometry serum profiling to distinguish non-small cell lung adenocarcinoma from squamous cell carcinoma patients and healthy controls. Sera were obtained from 19 adenocarcinoma patients, 24 squamous cell carcinoma patients, and 21 controls. Identifications of significant mass-to-charge ratio (m/z) peak differences between these groups were performed using t-tests. A "leave one out" cross-validation procedure yielded discriminatory lung adenocarcinoma versus squamous cell carcinoma p and ROC curve values of < .0001 and 0.92, respectively. Test sensitivity and specificity were 84% and 79%, respectively. This approach could aid in lung cancer diagnosis and sub-typing.

引用

页码：180 / 188

页数：9

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