IL-1 and atherosclerosis: a murine twist to an evolving human story

被引：33

作者：

Rader, Daniel J. ^{[1
,2
]}

机构：

[1] Univ Penn, Dept Med, Perelman Sch Med, Philadelphia, PA 19104 USA

[2] Univ Penn, Perelman Sch Med, Inst Translat Med & Therapeut, Philadelphia, PA 19104 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2012年 / 122卷 / 01期

关键词：

INTERLEUKIN-1 RECEPTOR ANTAGONIST; NLRP3; INFLAMMASOMES; INFLAMMATION; PATHOGENESIS; CANAKINUMAB; CRYSTALS; DISEASE;

D O I：

10.1172/JCI61163

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Inflammation is a critical component of atherosclerosis. IL-1 is a classic proinflammatory cytokine that has been linked to atherosclerosis. A clinical trial has been launched in which an antibody specific for IL-1 beta is being studied for its effects on cardiovascular events in patients with atherosclerosis. In this issue of the JCI, Alexander et al. report that mice lacking the receptor for IL-1 unexpectedly have features of advanced atherosclerosis that suggest the atherosclerotic plaques may be less stable. These findings illustrate the complexity of inflammatory pathways in atherosclerosis and suggest the need for careful calibration of antiinflammatory approaches to atherosclerosis.

引用

页码：27 / 30

页数：4

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