Core Cross-linked Polyethylene Glycol Oleate Micelles as Novel Drug Carriers

被引：0
作者：
Guo, Yanling [1 ]
Wang, Baoqi [2 ]
Zhao, Jun [3 ]
Cui, Zhaoshan [2 ]
机构：
[1] Tianjin Univ Sci & Technol, Coll Sci, Tianjin 300457, Peoples R China
[2] Tianjin Univ Sci & Technol, Coll Mat Sci & Chem Engn, Tianjin 300457, Peoples R China
[3] Hebei Univ Sci & Technol, Coll Polytech, Shijiazhuang, Hebei 050035, Peoples R China
来源：
APPLICATION OF CHEMICAL ENGINEERING, PTS 1-3 | 2011年 / 236-238卷
关键词：
Polyethylene Glycol Oleate; core cross-linked; micelles; controlled release; BLOCK-COPOLYMERS;
D O I：
10.4028/www.scientific.net/AMR.236-238.1770
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
Polyethylene Glycol Oleate was synthesized by esterification of polyethylene glycol and Oil acid using DMAP as a catalyst. The double bonds of the product in the core of micelles were cross-linked by the initiation of (NH4)(2)S2O8 during the micelles formed. Applications of the noncross-linked and cross-linked polyethylene glycol oleate in drug delivery were studied, which indicates that drug efficiency decreased after micelles were core cross-linked, but release rate of MTX from core cross-linked micelles seems slower than that from noncross-linked micelles.
引用
收藏
页码：1770 / +
页数：2
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