Anti-tumor activities of andrographolide, a diterpene from Andrographis paniculata, by inducing apoptosis and inhibiting VEGF level

被引：0
作者：
Zhao, Feng [1 ,2 ]
He, En-Qi [1 ]
Wang, Lu [1 ]
Liu, Ke [1 ,2 ]
机构：
[1] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China
[2] Yantai Target Drug Res Co Ltd, Yantai 264006, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2008年 / 10卷 / 05期
关键词：
andrographolide; anti-tumor activity; apoptosis; caspase; 3; bax; bcl-2;
D O I：
10.1080/10286020801948334
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Andrographolide (1), a diterpenoid lactone isolated from a traditional herb (Andrographis paniculata), is known to possess potent anti-inflammatory activity. In this study, we investigated the anti-tumor effect of 1 on various cancer cell lines in vitro. It induced apoptosis of prostate cancer (PC-3) cells (the most sensitive cell line among the cell lines screened) via the activation of caspase 3, up-regulation of bax, and down-regulation of bcl-2. Furthermore, its inhibitory activity on the level of vascular endothelial growth factor was also verified by ELISA.
引用
收藏
页码：473 / 479
页数：7
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