Premium ethylcellulose polymer based architectures at work in drug delivery

被引：65
作者：
Adeleke, Oluwatoyin A. [1 ,2 ]
机构：
[1] NIAID, Immunobiol Sect, Lab Parasit Dis, NIH,US Dept HHS, 9000 Rockville Pike, Bethesda, MD 20892 USA
[2] Sefako Makgatho Hlth Sci Univ, Sch Pharm, Div Pharmaceut Sci, ZA-0208 Pretoria, South Africa
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS-X | 2019年 / 1卷
基金：
新加坡国家研究基金会;
关键词：
Hydrophobic biomaterial; Cellulose derivative; Polymeric drug delivery; Pharmaceutical excipient; Polymeric biomaterial; IN-VIVO EVALUATION; RELEASE MATRIX TABLETS; ETHYL CELLULOSE NANOPARTICLES; MUCOADHESIVE BUCCAL FILM; OSMOTIC PUMP TABLETS; SITU FORMING GEL; VITRO CHARACTERIZATION; TRANSDERMAL PATCHES; DIRECT COMPRESSION; BIOFILM FORMATION;
D O I：
10.1016/j.ijpx.2019.100023
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Premium ethylcellulose polymers are hydrophobic cellulose ether based biomaterials widely employed as bio-compatible templates for the design of novel drug delivery systems. They are classified as United States Food and Drug Administration Generally-Recognized-As-Safe chemical substances and have been extensively utilized within the biomedical and pharmaceutical industries for over half a century. They have so far demonstrated the potential to modulate and improve the physiological performance of bioactives leading to the desired enhanced prophylactic and therapeutic outcomes. This review therefore presents a scholarly survey of inter-disciplinary developments focused on the functionalities of ethylcellulose polymers as biomaterials useful for the design of smart delivery architectures for relevant pharmacotherapeutic biomedical applications. Emphasis was placed on evaluating scientific resources related to recent advancements and future directions associated with its applications as delivery systems for drugs and biologics within the past decade thus complementing other specialized reviews showcasing the theme.
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页数：15
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