A Phosphine-Mediated Synthesis of 1,4-Oxazepine- and 1,5-Oxazocine-Based Sugar Hybrids from Deoxysugar Azides

被引：2

作者：

Kurhade, Suresh E. ^{[1
,3
]}

Salunkhe, Videsh T. ^{[1
]}

Siddaiah, V. ^{[3
]}

Bhuniya, Debnath ^{[1
]}

Reddy, D. Srinivasa ^{[1
,2
]}

机构：

[1] Advinus Therapeut Ltd, Discovery Chem, Pune 411057, Maharashtra, India

[2] CSIR, Natl Chem Lab, Pune 411008, Maharashtra, India

[3] Andhra Univ, Dept Organ Chem, Visakhapatnam 530003, Andhra Pradesh, India

来源：

SYNTHESIS-STUTTGART | 2011年 / 21期

关键词：

tandem reactions; heterocycles; carbohydrates; alkynes; oxazepines; oxazocines; azides; BETA-D-GLUCOSE; POLYCYCLIC HETEROCYCLES; CYCLOADDITION REACTION; ENKEPHALIN; DESIGN; BRAIN; DERIVATIVES; SCAFFOLDS; GLYCATION; DELIVERY;

D O I：

10.1055/s-0030-1260218

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and convenient method was developed for the synthesis of novel 1,4-oxazepine- and 1,5-oxazocine-based sugar hybrids from readily available deoxysugar azides by means of tributylphosphine-mediated tandem reactions. The resulting glycoconjugates might be useful in increasing the diversity of sugar backbones, and could find applications as potential glycomimetics and in drug discovery.

引用

页码：3523 / 3529

页数：7

共 2 条

[1] Sodium hydride-mediated synthesis of 1,5-diaryl-1,2,3-triazoles from anti-3-aryl-2,3-dibromopropanoic acids and organic azides
Xue-Zhi Cheng
Wei Liu
Zhen-Dong Huang
Chun-Xiang Kuang
Chinese Chemical Letters, 2013, 24 (08) : 764 - 766
[2] Sodium hydride-mediated synthesis of 1,5-diaryl-1,2,3-triazoles from anti-3-aryl-2,3-dibromopropanoic acids and organic azides
Cheng, Xue-Zhi
Liu, Wei
Huang, Zhen-Dong
Kuang, Chun-Xiang
CHINESE CHEMICAL LETTERS, 2013, 24 (08) : 764 - 766

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