Regulatory roles of mast cells in immune responses

被引：29

作者：

Morita, Hideaki ^{[1
,2
]}

Saito, Hirohisa ^{[1
]}

Matsumoto, Kenji ^{[1
]}

Nakae, Susumu ^{[3
,4
]}

机构：

[1] Natl Res Inst Child Hlth & Dev, Dept Allergy & Clin Immunol, Tokyo 1578535, Japan

[2] Univ Zurich, Swiss Inst Allergy & Asthma Res, CH-7270 Davos, Switzerland

[3] Univ Tokyo, Inst Med Sci, Ctr Expt Med & Syst Biol, Lab Syst Biol, Tokyo 1088639, Japan

[4] Japan Sci & Technol Agcy, Precursory Res Embryon Sci & Technol PRESTO, Kawaguchi, Saitama 3320012, Japan

来源：

SEMINARS IN IMMUNOPATHOLOGY | 2016年 / 38卷 / 05期

基金：

日本科学技术振兴机构;

关键词：

Mast cell; Rejection; Graft-versus-host disease; Contact hypersensitivity; Innate-type allergic airway inflammation; DELAYED-TYPE HYPERSENSITIVITY; VERSUS-HOST-DISEASE; TUMOR-NECROSIS-FACTOR; DUST MITE ALLERGEN; CONTACT SENSITIVITY; T-CELLS; DEFICIENT MICE; CHRONIC INFLAMMATION; LUNG INFLAMMATION; MEDIATE TOLERANCE;

D O I：

10.1007/s00281-016-0566-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mast cells are important immune cells for host defense through activation of innate immunity (via toll-like receptors or complement receptors) and acquired immunity (via Fc epsilon RI). Conversely, mast cells also act as effector cells that exacerbate development of allergic or autoimmune disorders. Yet, several lines of evidence show that mast cells act as regulatory cells to suppress certain inflammatory diseases. Here, we review the mechanisms by which mast cells suppress diseases.

引用

页码：623 / 629

页数：7

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