Design, Synthesis and Structure of Novel Para-Quinones and their Antibacterial Activity

被引：4

作者：

Pandurangan, Komala ^{[1
]}

Murnaghan, Kevin D. ^{[1
]}

Walshe, Aurora ^{[1
]}

Mueller-Bunz, Helge ^{[1
]}

Paradisi, Francesca ^{[1
]}

Morgan, Grace G. ^{[1
]}

机构：

[1] Univ Coll Dublin, Sch Chem & Chem Biol, CSCB, Dublin 4, Ireland

来源：

CHEMICAL BIOLOGY & DRUG DESIGN | 2011年 / 78卷 / 05期

关键词：

antibacterial; crystal structure; Escherichia coli; paraquinone; Staphylococcus aureus; DERIVATIVES; NAPHTHOQUINONES; BIOSYNTHESIS; EFFICIENT; AGENTS;

D O I：

10.1111/j.1747-0285.2011.01187.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eight new para-quinones and one known analogue have been synthesized from p-chloranil. Five have been structurally characterized by single crystal diffraction, and a range of ligand folding is observed. All nine have been tested for their potency towards Gram(+) S. aureus and Gram(-) E. coli. Quinones 3, 6, 7 and 8 have shown activity towards S. aureus and quinones 3 and 8 also show good activity towards E. coli.

引用

页码：787 / 799

页数：13

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