A new rosamine-based fluorescent chemodosimeter for hydrogen sulfide and its bioimaging in live cells

被引：36

作者：

Cheng, Junye ^{[1
]}

Song, Jianhua ^{[1
]}

Niu, Huawei ^{[1
]}

Tang, Jun ^{[1
]}

Zhang, Di ^{[2
]}

Zhao, Yufen ^{[1
,3
]}

Ye, Yong ^{[1
,3
]}

机构：

[1] Zhengzhou Univ, Coll Chem & Mol Engn, Phosphorus Chem Engn Res Ctr Henan Prov, Zhengzhou, Peoples R China

[2] Henan Acad Agr Sci, Inst Agr Qual Stand & Testing Technol, Zhengzhou, Peoples R China

[3] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing, Peoples R China

来源：

NEW JOURNAL OF CHEMISTRY | 2016年 / 40卷 / 07期

关键词：

CYSTATHIONINE GAMMA-LYASE; LIVING CELLS; PROBE; H2S; DISEASE; REDUCTION; ANIONS; SENSOR; STATE; MICE;

D O I：

10.1039/c6nj00177g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new probe ( RosN(3)), which displayed excellent selectivity to H2S in mixed aqueous media, was synthesized. This method employed the H2S-mediated reduction of azides to amines, resulting in fluorescence quenching. The probe exhibited high H2S selectivity over other common anions and biothiols. The detection limit was measured to be 0.25 mu M. Furthermore, the live cell imaging results demonstrated its potential for practical application in biological systems.

引用

页码：6384 / 6388

页数：5

共 42 条

[1] Chemiluminescent Detection of Enzymatically Produced Hydrogen Sulfide: Substrate Hydrogen Bonding Influences Selectivity for H2S over Biological Thiols [J].

Bailey, T. Spencer ;

Pluth, Michael D. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, 135 (44) :16697-16704

[2] Hydrogen sulfide gas has cell growth regulatory role [J].

Baskar, Rajamanickam ;

Bian, Jinsong .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2011, 656 (1-3) :5-9

[3] Measurement of reduced sulphur compounds contained in aqueous matrices by direct injection into a gas chromatograph with a flame photometric detector [J].

Bérubé, PR ;

Parkinson, PD ;

Hall, ER .

JOURNAL OF CHROMATOGRAPHY A, 1999, 830 (02) :485-489

[4] H2S induces a suspended animation-like state in mice [J].

Blackstone, E ;

Morrison, M ;

Roth, MB .

SCIENCE, 2005, 308 (5721) :518-518

[5] A sensitivity tuneable tetraphenylethene-based fluorescent probe for directly indicating the concentration of hydrogen sulfide [J].

Cai, Yunbo ;

Li, Lingzhi ;

Wang, Zongtan ;

Sun, Jing Zhi ;

Qin, Anjun ;

Tang, Ben Zhong .

CHEMICAL COMMUNICATIONS, 2014, 50 (64) :8892-8895

[6] A Near-Infrared Fluorescence Turn-On Sensor for Sulfide Anions [J].

Cao, Xiaowei ;

Lin, Weiying ;

He, Longwei .

ORGANIC LETTERS, 2011, 13 (17) :4716-4719

[7] Microwave-Assisted Synthesis and Spectroscopic Properties of 4′-Substituted Rosamine Fluorophores and Naphthyl Analogues [J].

Cardoso, Ines C. S. ;

Amorim, Ana L. ;

Queiros, Carla ;

Lopes, Silvia C. ;

Gameiro, Paula ;

de Castro, Baltazar ;

Rangel, Maria ;

Silva, Ana M. G. .

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2012, 2012 (29) :5810-5817

[8] Chemoselective reduction-based fluorescence probe for detection of hydrogen sulfide in living cells [J].

Chen, Bifeng ;

Lv, Cong ;

Tang, Xinjing .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2012, 404 (6-7) :1919-1923

[9] A new resorufin-based spectroscopic probe for simple and sensitive detection of benzoyl peroxide via deboronation [J].

Chen, Wei ;

Li, Zhao ;

Shi, Wen ;

Ma, Huimin .

CHEMICAL COMMUNICATIONS, 2012, 48 (22) :2809-2811

[10] A Ratiometric Fluorescent Probe for Rapid Detection of Hydrogen Sulfide in Mitochondria [J].

Chen, Yuncong ;

Zhu, Chengcheng ;

Yang, Zhenghao ;

Chen, Junjie ;

He, Yafeng ;

Jiao, Yang ;

He, Weijiang ;

Qiu, Lin ;

Cen, Jiajie ;

Guo, Zijian .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, 52 (06) :1688-1691

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