A new rosamine-based fluorescent chemodosimeter for hydrogen sulfide and its bioimaging in live cells

被引：36
作者：
Cheng, Junye [1 ]
Song, Jianhua [1 ]
Niu, Huawei [1 ]
Tang, Jun [1 ]
Zhang, Di [2 ]
Zhao, Yufen [1 ,3 ]
Ye, Yong [1 ,3 ]
机构：
[1] Zhengzhou Univ, Coll Chem & Mol Engn, Phosphorus Chem Engn Res Ctr Henan Prov, Zhengzhou, Peoples R China
[2] Henan Acad Agr Sci, Inst Agr Qual Stand & Testing Technol, Zhengzhou, Peoples R China
[3] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing, Peoples R China
来源：
NEW JOURNAL OF CHEMISTRY | 2016年 / 40卷 / 07期
关键词：
CYSTATHIONINE GAMMA-LYASE; LIVING CELLS; PROBE; H2S; DISEASE; REDUCTION; ANIONS; SENSOR; STATE; MICE;
D O I：
10.1039/c6nj00177g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new probe ( RosN(3)), which displayed excellent selectivity to H2S in mixed aqueous media, was synthesized. This method employed the H2S-mediated reduction of azides to amines, resulting in fluorescence quenching. The probe exhibited high H2S selectivity over other common anions and biothiols. The detection limit was measured to be 0.25 mu M. Furthermore, the live cell imaging results demonstrated its potential for practical application in biological systems.
引用
收藏
页码：6384 / 6388
页数：5
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