Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant

被引：502

作者：

Suzuki, Rigel ^{[1
]}

Yamasoba, Daichi ^{[2
,3
]}

Kimura, Izumi ^{[2
]}

Wang, Lei ^{[4
,5
]}

Kishimoto, Mai ^{[6
]}

Ito, Jumpei ^{[2
]}

Morioka, Yuhei ^{[1
]}

Nao, Naganori ^{[7
,8
]}

Nasser, Hesham ^{[9
,10
]}

Uriu, Keiya ^{[2
,11
]}

Kosugi, Yusuke ^{[2
,12
,13
]}

Tsuda, Masumi ^{[4
,5
]}

Orba, Yasuko ^{[6
,14
]}

Sasaki, Michihito ^{[6
,14
]}

Shimizu, Ryo ^{[9
]}

Kawabata, Ryoko ^{[15
]}

Yoshimatsu, Kumiko ^{[16
]}

Asakura, Hiroyuki ^{[17
]}

Nagashima, Mami ^{[17
]}

Sadamasu, Kenji ^{[17
]}

Yoshimura, Kazuhisa ^{[17
]}

Sawa, Hirofumi ^{[6
,7
,8
,14
]}

Ikeda, Terumasa ^{[9
]}

Irie, Takashi ^{[15
]}

Matsuno, Keita ^{[8
,14
,18
]}

Tanaka, Shinya ^{[4
,5
]}

Fukuhara, Takasuke ^{[1
]}

Sato, Kei ^{[2
,11
,19
]}

机构：

[1] Hokkaido Univ, Grad Sch Med, Dept Microbiol & Immunol, Sapporo, Hokkaido, Japan

[2] Univ Tokyo, Int Res Ctr Infect Dis, Inst Med Sci, Dept Infect Dis Control,Div Syst Virol, Tokyo, Japan

[3] Kobe Univ, Fac Med, Kobe, Hyogo, Japan

[4] Hokkaido Univ, Fac Med, Dept Canc Pathol, Sapporo, Hokkaido, Japan

[5] Hokkaido Univ, Inst Chem React Design & Discovery WPI ICReDD, Sapporo, Hokkaido, Japan

[6] Hokkaido Univ, Int Inst Zoonosis Control, Div Mol Pathobiol, Sapporo, Hokkaido, Japan

[7] Hokkaido Univ, Int Inst Zoonosis Control, Div Int Res Promot, Sapporo, Hokkaido, Japan

[8] Hokkaido Univ, Hlth Res Ctr 1, Sapporo, Hokkaido, Japan

[9] Kumamoto Univ, Joint Res Ctr Human Retrovirus Infect, Div Mol Virol & Genet, Kumamoto, Japan

[10] Suez Canal Univ, Fac Med, Dept Clin Pathol, Ismailia, Egypt

[11] Univ Tokyo, Grad Sch Med, Tokyo, Japan

[12] Kyoto Univ, Inst Frontier Life & Med Sci, Lab Syst Virol, Kyoto, Japan

[13] Kyoto Univ, Grad Sch Pharmaceut Sci, Kyoto, Japan

[14] Hokkaido Univ, Int Inst Zoonosis Control, Int Collaborat Unit, Sapporo, Hokkaido, Japan

[15] Hiroshima Univ, Inst Biomed & Hlth Sci, Hiroshima, Japan

[16] Hokkaido Univ, Inst Genet Med, Sapporo, Hokkaido, Japan

[17] Tokyo Metropolitan Inst Publ Hlth, Tokyo, Japan

[18] Hokkaido Univ, Int Inst Zoonosis Control, Div Risk Anal & Management, Sapporo, Hokkaido, Japan

[19] Japan Sci & Technol Agcy, CREST, Saitama, Japan

来源：

NATURE | 2022年 / 603卷 / 7902期

关键词：

CELLS;

D O I：

10.1038/s41586-022-04462-1

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The emergence of the Omicron variant of SARS-CoV-2 is an urgent global health concern(1). In this study, our statistical modelling suggests that Omicron has spread more rapidly than the Delta variant in several countries including South Africa. Cell culture experiments showed Omicron to be less fusogenic than Delta and than an ancestral strain of SARS-CoV-2.Although the spike (S) protein of Delta is efficiently cleaved into two subunits, which facilitates cell-cell fusion(2,3), the Omicron S protein was less efficiently cleaved compared to the S proteins of Delta and ancestral SARS-CoV-2. Furthermore, in a hamster model, Omicron showed decreased lung infectivity and was less pathogenic compared to Delta and ancestral SARS-CoV-2. Our multiscale investigations reveal the virological characteristics of Omicron, including rapid growth in the human population, lower fusogenicity and attenuated pathogenicity.

引用

页码：700 / +

页数：23

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