Effects of human PTH(1-34) and bisphosphonate on the osteopenic rat model

被引：10
作者：
Tanizawa, T
Yamamoto, N
Takano, Y
Mashiba, T
Zhang, L
Nishida, S
Endo, N
Takahashi, HE
Fujimoto, R
Hori, M
机构：
[1] Niigata Univ, Sch Med, Dept Orthoped Surg, Niigata 9518520, Japan
[2] Yamanouchi Pharmaceut Co Ltd, Res Lab, Tokyo, Japan
[3] Asahi Chem Ind Co Ltd, Lab Bone Metab, Shizuoka, Japan
来源：
TOXICOLOGY LETTERS | 1998年 / 103卷
关键词：
human PTH; bisphosphonate; ovariectomy; histomorphometry; osteoporosis; rats;
D O I：
10.1016/S0378-4274(98)00241-0
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
It has been demonstrated that the intermittent administration of human parathyroid hormone (hPTH) is beneficial for restoration of bone mass in osteoporotic patients. The mechanisms of anabolic effects of hPTH have been determined by ovariectomized rat models and other larger remodeling animals. However, treatment with hPTH may increase the cancellous bone mass at the expense of cortical bone mass and cessation of the treatment results in rapid bone loss. Efforts have been made to maintain newly formed bone mass after withdrawal of the hPTH treatment. These issues are not well understood. In this article, the authors would like to represent previous studies of their own and others concerning these issues. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
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页码：399 / 403
页数：5
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