Xenopus brain factor-2 controls mesoderm, forebrain and neural crest development

被引：36
|
作者：
Gómez-Skarmeta, JL
de la Calle-Mustienes, E
Modolell, J
Mayor, R
机构：
[1] Univ Chile, Fac Ciencias, Lab Biol Desarrollo, Santiago, Chile
[2] CSIC, Ctr Biol Mol Severo Ochoa, E-28049 Madrid, Spain
[3] Univ Autonoma Madrid, E-28049 Madrid, Spain
来源：
MECHANISMS OF DEVELOPMENT | 1999年 / 80卷 / 01期
关键词：
Xbf2; mesoderm; neural induction; neural crest; Xenopus;
D O I：
10.1016/S0925-4773(98)00190-7
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The forkhead type Brain Factor 2 from mouse and chicken help pattern the forebrain, optic vesicle and kidney. We have isolated a Xenopus homolog (Xbf2) and found that during gastrulation it is expressed in the dorsolateral mesoderm, where it helps specify this territory by downregulating BMP-4 and its downstream genes. Indeed, XbfZ overexpression caused partial axis duplication. Interference with BMP-4 signaling also occurs in isolated animal caps, since Xbf2 induces neural tissue. Within the neurula forebrain, Xbf2 and the related Xbf1 gene are expressed in the contiguous diencephalic and telencephalic territories, respectively, and each gene represses the other. Finally, Xbf2 seems to participate in the control of neural crest migration. Our data suggest that XBF2 interferes with BMP-4 signaling, both in mesoderm and ectoderm. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：15 / 27
页数：13
相关论文
共 50 条
  • [21] Neural crest can form cartilages normally derived from mesoderm during development of the avian head skeleton
    Schneider, RA
    DEVELOPMENTAL BIOLOGY, 1999, 208 (02) : 441 - 455
  • [22] Combinatorial activity of Six1-2-4 genes in cephalic neural crest cells controls craniofacial and brain development
    Garcez, Ricardo C.
    Le Douarin, Nicole M.
    Creuzet, Sophie E.
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2014, 71 (11) : 2149 - 2164
  • [23] Hypoxia inducible factor-2α importance for migration, proliferation, and self-renewal of trunk neural crest cells
    Niklasson, Camilla U.
    Fredlund, Elina
    Monni, Emanuela
    Lindvall, Jessica M.
    Kokaia, Zaal
    Hammarlund, Emma U.
    Bronner, Marianne E.
    Mohlin, Sofie
    DEVELOPMENTAL DYNAMICS, 2021, 250 (02) : 191 - 236
  • [24] Combinatorial activity of Six1-2-4 genes in cephalic neural crest cells controls craniofacial and brain development
    Ricardo C. Garcez
    Nicole M. Le Douarin
    Sophie E. Creuzet
    Cellular and Molecular Life Sciences, 2014, 71 : 2149 - 2164
  • [25] Repulsive guidance molecule A (RGM A) and its receptor neogenin during neural and neural crest cell development of Xenopus laevis
    Gessert, Susanne
    Maurus, Daniel
    Kuehl, Michael
    BIOLOGY OF THE CELL, 2008, 100 (11) : 659 - 673
  • [26] Snail2 controls mesodermal BMP/Wnt induction of neural crest
    Shi, Jianli
    Severson, Courtney
    Yang, Jianxia
    Wedlich, Doris
    Klymkowsky, Michael W.
    DEVELOPMENT, 2011, 138 (15): : 3135 - 3145
  • [27] CYCLOPAMINE, A STEROIDAL ALKALOID, DISRUPTS DEVELOPMENT OF CRANIAL NEURAL CREST CELLS IN XENOPUS
    DUNN, MK
    MERCOLA, M
    MOORE, DD
    DEVELOPMENTAL DYNAMICS, 1995, 202 (03) : 255 - 270
  • [28] Xenopus Teashirt1 regulates posterior identity in brain and cranial neural crest
    Koebernick, Katja
    Kashef, Jubin
    Pieler, Tomas
    Wedlich, Doris
    DEVELOPMENTAL BIOLOGY, 2006, 298 (01) : 312 - 326
  • [29] Xiro, a Xenopus homolog of the Drosophila Iroquois complex genes, controls development at the neural plate
    Gómez-Skarmeta, JL
    Glavic, A
    de la Calle-Mustienes, E
    Modolell, J
    Mayor, R
    EMBO JOURNAL, 1998, 17 (01) : 181 - 190
  • [30] The LIM homeodomain protein Lim-1 is widely expressed in neural, neural crest and mesoderm derivatives in vertebrate development
    Karavanov, AA
    SaintJeannet, JP
    Karavanova, I
    Taira, M
    Dawid, IB
    INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 1996, 40 (02) : 453 - 461
12345