Efficient synthesis of novel heterocyclic dihydropyrimidine-2,4,5(3H)-trione and tetrahydro-2-thioxopyrimidine-4,5-dione derivatives

被引：2

作者：

Mehrabi, Hossein ^{[1
]}

Alizadeh-bami, Farzaneh ^{[1
]}

机构：

[1] Vali E Asr Univ Rafsanjan, Dept Chem, Rafsanjan 77176, Iran

来源：

JOURNAL OF THE IRANIAN CHEMICAL SOCIETY | 2015年 / 12卷 / 07期

关键词：

Dihydropyrimidine-2,4,5(3H)-triones; Tetrahydro-2-thioxopyrimidine-4,5-dione; Three-component reaction; Phenyl isocyanate; Phenyl isothiocyanate; Ethyl bromopyruvate; METHANOL; ACID;

D O I：

10.1007/s13738-015-0591-2

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel heterocyclic dihydropyrimidine-2,4,5(3H)-triones and tetrahydro-2-thioxopyrimidine-4,5-diones were synthesized via three-component reaction between appropriate amines, phenyl isocyanate or phenyl isothiocyanate, and ethyl bromopyruvate in DMF under reflux conditions without using additional bases or catalysts. All the products were obtained in good yield by simple and efficient procedure. The structures of all the synthesized compounds were established from advanced spectroscopic data.

引用

页码：1275 / 1279

页数：5

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