Lung transplantation from out-of-hospital non-heart-beating lung donors.: One-year experience and results

被引:52
作者
Gámez, P
Córdoba, M
Ussetti, P
Carreño, MC
Alfageme, F
Madrigal, L
Nuñez, JR
Calatayud, J
Ramos, M
Salas, C
Varela, A
机构
[1] Hosp Univ Puerta Hierro, Serv Cirugia Cardiovasc & Torac, Madrid 28035, Spain
[2] Hosp Univ Puerta Hierro, Serv Pneumol, Madrid 28035, Spain
[3] Hosp Univ Puerta Hierro, Rehabil Serv, Madrid 28035, Spain
[4] Hosp Univ Puerta Hierro, Dept Pathol, Madrid 28035, Spain
[5] Hosp Clin San Carlos, Transplant Coordinat, Madrid, Spain
关键词
D O I
10.1016/j.healun.2004.06.002
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
There is currently no method for preservation and functional evaluation of clinical out-of-hospital non-heart-beating lung donors (NHBLD) that can be applied practically and systematically in clinical lung transplantation programs. A new method of preservation and functional evaluation of the lung has been developed in NHBLD that is based on the knowledge of various experimental studies. Initially, the viability of lungs harvested this way was proved from preliminary functional and histologic tests. In November 2002, we started using lung allografts from non-heart-beating donors. Five lung transplantations (4 bipulmonary and 1 unipulmonary) were performed successfully. The short and mid-term results have been excellent and all recipients are alive. We report our initial experience, which we hope will be of help to those involved in clinical lung transplantation programs worldwide.
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收藏
页码:1098 / 1102
页数:5
相关论文
共 17 条
[1]   Non-heart-beating donors:: Estimated actual potential [J].
Alvarez, J ;
del Barrio, R ;
Arias, J ;
Vázquez, S ;
Sánchez, A ;
Iglesias, J ;
Barra, C ;
Ibarguren, C .
TRANSPLANTATION PROCEEDINGS, 2001, 33 (1-2) :1101-1103
[2]   A STRATEGY TO INCREASE THE DONOR POOL - USE OF CADAVER LUNGS FOR TRANSPLANTATION [J].
EGAN, TM ;
LAMBERT, CJ ;
REDDICK, R ;
ULICNY, KS ;
KEAGY, BA ;
WILCOX, BR .
ANNALS OF THORACIC SURGERY, 1991, 52 (05) :1113-1121
[3]  
Gamez Garcia P, 1998, Arch Bronconeumol, V34, P417
[4]   ETHICAL DILEMMAS IN ORGAN DONATION AND TRANSPLANTATION [J].
GRENVIK, A .
CRITICAL CARE MEDICINE, 1988, 16 (10) :1012-1018
[5]  
HARDY JD, 1963, JAMA-J AM MED ASSOC, V186, P1065
[6]  
KOOSTRA G, 1995, TRANSPL P, V27, P2965
[7]  
LECHNER JF, 1986, IN VITRO MODELS RESP, P143
[8]  
Love Robert B., 1995, Journal of Heart and Lung Transplantation, V14, pS88
[9]  
Organizacion Nacional de Trasplantes, 1995, DOC CONS ESP DON ORG
[10]  
Sanchez-Fructuoso AI, 2003, J NEPHROL, V16, P387